Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 24, Issue 11 , Pages 1221-1231 , November 2008

Histologic and Biomechanical Analysis of Anterior Cruciate Ligament Graft to Bone Healing in Skeletally Immature Sheep

  • Rupert Meller, M.D.

      Affiliations

    • Trauma Department, Hannover Medical School, Hannover, Germany
    • Corresponding Author InformationAddress correspondence and reprint requests to Rupert Meller, M.D., Trauma Department, Hannover Medical School (MHH), Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    • ,
  • Elmar Willbold, M.D.

      Affiliations

    • Orthopaedic Department, Hannover Medical School, Hannover, Germany
    • ,
  • Eric Hesse, M.D.

      Affiliations

    • Trauma Department, Hannover Medical School, Hannover, Germany
    • ,
  • Beatrix Dreymann, M.D.

      Affiliations

    • Orthopaedic Department, Hannover Medical School, Hannover, Germany
    • ,
  • Michael Fehr, M.D.

      Affiliations

    • Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany
    • ,
  • Carl Haasper, M.D.

      Affiliations

    • Trauma Department, Hannover Medical School, Hannover, Germany
    • ,
  • Christof Hurschler, M.D.

      Affiliations

    • Orthopaedic Department, Hannover Medical School, Hannover, Germany
    • ,
  • Christian Krettek, M.D., F.R.A.C.S., F.R.C.S.Ed.

      Affiliations

    • Trauma Department, Hannover Medical School, Hannover, Germany
    • ,
  • Frank Witte, M.D.

      Affiliations

    • Orthopaedic Department, Hannover Medical School, Hannover, Germany

Received 27 January 2008 ,Accepted 27 June 2008.

References 

  1. Chudik S, Beasley L, Potter H, Wickiewicz T, Warren R, Rodeo S. The influence of femoral technique for graft placement on anterior cruciate ligament reconstruction using a skeletally immature canine model with a rapidly growing physis. Arthroscopy. 2007;23:1309–1319.e1Available online at www.arthroscopyjournal.org.
  2. Bales CP, Guettler JH, Moorman CT. Anterior cruciate ligament injuries in children with open physes: Evolving strategies of treatment. Am J Sports Med. 2004;32:1978–1985
  3. Simonian PT, Metcalf MH, Larson RV. Anterior cruciate ligament injuries in the skeletally immature patient. Am J Orthop. 1999;28:624–628
  4. Nottage WM, Matsuura PA. Management of complete traumatic anterior cruciate ligament tears in the skeletally immature patient: Current concepts and review of the literature. Arthroscopy. 1994;10:569–573
  5. Behr CT, Potter HG, Paletta GA. The relationship of the femoral origin of the anterior cruciate ligament and the distal femoral physeal plate in the skeletally immature knee (An anatomic study). Am J Sports Med. 2001;29:781–787
  6. Weiler A, Hoffmann RF, Bail HJ, Rehm O, Sudkamp NP. Tendon healing in a bone tunnel (Part II: Histologic analysis after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep). Arthroscopy. 2002;18:124–135
  7. Weiler A, Peine R, Pashmineh-Azar A, Abel C, Sudkamp NP, Hoffmann RF. Tendon healing in a bone tunnel (Part I: Biomechanical results after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep). Arthroscopy. 2002;18:113–123
  8. Goradia VK, Rochat MC, Grana WA, Rohrer MD, Prasad HS. Tendon-to-bone healing of a semitendinosus tendon autograft used for ACL reconstruction in a sheep model. Am J Knee Surg. 2000;13:143–151
  9. Walsh WR, Stephens P, Vizesi F, Bruce W, Huckle J, Yu Y. Effects of low-intensity pulsed ultrasound on tendon-bone healing in an intra-articular sheep knee model. Arthroscopy. 2007;23:197–204
  10. Edwards TB, Greene CC, Baratta RV, Zieske A, Willis RB. The effect of placing a tensioned graft across open growth plates (A gross and histologic analysis). J Bone Joint Surg Am. 2001;83:725–734
  11. Kawamura S, Ying L, Kim HJ, Dynybil C, Rodeo SA. Macrophages accumulate in the early phase of tendon-bone healing. J Orthop Res. 2005;23:1425–1432
  12. Birk DE, Mayne R. Localization of collagen types I, III and V during tendon development (Changes in collagen types I and III are correlated with changes in fibril diameter). Eur J Cell Biol. 1997;72:352–361
  13. Ingraham JM, Hauck RM, Ehrlich HP. Is the tendon embryogenesis process resurrected during tendon healing?. Plast Reconstr Surg. 2003;112:844–854
  14. Rodeo SA, Kawamura S, Kim HJ, Dynybil C, Ying L. Tendon healing in a bone tunnel differs at the tunnel entrance versus the tunnel exit: An effect of graft-tunnel motion?. Am J Sports Med. 2006;34:1790–1800
  15. Cummings JF, Grood ES. The progression of anterior translation after anterior cruciate ligament reconstruction in a caprine model. J Orthop Res. 2002;20:1003–1008
  16. Tapper JE, Fukushima S, Azuma H, et al. Dynamic in vivo kinematics of the intact ovine stifle joint. J Orthop Res. 2006;24:782–792
  17. Weiler A, Unterhauser FN, Bail HJ, Huning M, Haas NP. Alpha-smooth muscle actin is expressed by fibroblastic cells of the ovine anterior cruciate ligament and its free tendon graft during remodeling. J Orthop Res. 2002;20:310–317
  18. Weiler A, Forster C, Hunt P, et al. The influence of locally applied platelet-derived growth factor-BB on free tendon graft remodeling after anterior cruciate ligament reconstruction. Am J Sports Med. 2004;32:881–891
  19. Yoshikawa T, Tohyama H, Katsura T, et al. Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semitendinosus tendon graft after anterior cruciate ligament reconstruction in sheep. Am J Sports Med. 2006;34:1918–1925

 Supported by the Research Commission of Hannover Medical School, Hannover, Germany. The authors report no conflict of interest.

PII: S0749-8063(08)00515-X

doi: 10.1016/j.arthro.2008.06.021

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 24, Issue 11 , Pages 1221-1231 , November 2008

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