Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 22, Issue 7 , Pages 693-699 , July 2006

In Vitro Exposure to 0.5% Bupivacaine Is Cytotoxic to Bovine Articular Chondrocytes

  • Constance R. Chu, M.D.

      Affiliations

    • Cartilage Restoration Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
    • Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
    • Corresponding Author InformationAddress correspondence and reprint requests to Constance R. Chu, M.D., Director, Cartilage Restoration Laboratory, 5200 Centre Ave, Suite 415, Pittsburgh, PA 15232, U.S.A.
    • ,
  • Nicholas J. Izzo, Ph.D.

      Affiliations

    • Cartilage Restoration Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
    • Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
    • ,
  • Nicole E. Papas, B.S.

      Affiliations

    • Cartilage Restoration Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
    • Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
    • ,
  • Freddie H. Fu, M.D.

      Affiliations

    • Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.

References 

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  2. Chu CR , Convery FR , Akeson WH , Meyers M , Amiel D . Articular cartilage transplantation (Clinical results in the knee) . Clin Orthop . 1999;360:159–168
  3. Goldring MB . The role of the chondrocyte in osteoarthritis . Arthritis Rheum . 2000;43:1916–1926
  4. Chu CR , Monosov AZ , Amiel D . In situ assessment of cell viability within biodegradable polylactic acid polymer matrices . Biomaterials . 1995;16:1381–1384
  5. Masuda K , Sah RL , Hejna MJ , Thonar EJ . A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes (The alginate-recovered-chondrocyte (ARC) method) . J Orthop Res . 2003;21:139–148
  6. Curl WW , Krome J , Gordon ES , Rushing J , Smith BP , Poehling GG . Cartilage injuries (A review of 31,516 knee arthroscopies) . Arthroscopy . 1997;13:456–460
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  8. Chu CR , Lin D , Geisler JL , Chu CT , Fu FH , Pan Y . Arthroscopic microscopy of articular cartilage using optical coherence tomography . Am J Sports Med . 2004;32:699–709
  9. Aasbo V , Raeder JC , Grogaard B , Roise O . No additional analgesic effect of intra-articular morphine or bupivacaine compared with placebo after elective knee arthroscopy . Acta Anaesthesiol Scand . 1996;40:585–588
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  11. Talu GK , Ozyalcin S , Koltka K , et al.   Comparison of efficacy of intraarticular application of tenoxicam, bupivacaine and tenoxicam (bupivacaine combination in arthroscopic knee surgery) . Knee Surg Sports Traumatol Arthrosc . 2002;10:355–360
  12. Rasmussen S , Larsen AS , Thomsen ST , Kehlet H . Intra-articular glucocorticoid, bupivacaine and morphine reduces pain, inflammatory response and convalescence after arthroscopic meniscectomy . Pain . 1998;78:131–134
  13. Calmet J , Esteve C , Boada S , Gine J . Analgesic effect of intra-articular ketorolac in knee arthroscopy (Comparison of morphine and bupivacaine) . Knee Surg Sports Traumatol Arthrosc . 2004;12:552–555
  14. Denti M , Randelli P , Bigoni M , Vitale G , Marino MR , Fraschini N . Pre- and postoperative intra-articular analgesia for arthroscopic surgery of the knee and arthroscopy-assisted anterior cruciate ligament reconstruction (A double-blind randomized, prospective study) . Knee Surg Sports Traumatol Arthrosc . 1997;5:206–212
  15. Marchal JM , Delgado-Martinez AD , Poncela M , Valenzuela J , de Dios Luna J . Does the type of arthroscopic surgery modify the analgesic effect of intraarticular morphine and bupivacaine? (A preliminary study) . Clin J Pain . 2003;19:240–246
  16. Mather LE , Chang DH . Cardiotoxicity with modern local anaesthetics (Is there a safer choice?) . Drugs . 2001;61:333–342
  17. Soltesz EG , van Pelt F , Byrne JG . Emergent cardiopulmonary bypass for bupivacaine cardiotoxicity . J Cardiothorac Vasc Anesth . 2003;17:357–358
  18. Debruyne D , Moulin MA , Carmes C , Beguin JA , Locker B . Monitoring serum bupivacaine levels during arthroscopy . Eur J Clin Pharmacol . 1985;27:733–735
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PII: S0749-8063(06)00618-9

doi: 10.1016/j.arthro.2006.05.006

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 22, Issue 7 , Pages 693-699 , July 2006

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