Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 24, Issue 1 , Pages 69-76 , January 2008

A Novel Cell Delivery System Using Magnetically Labeled Mesenchymal Stem Cells and an External Magnetic Device for Clinical Cartilage Repair

  • Takaaki Kobayashi, M.D.

      Affiliations

    • Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    • ,
  • Mitsuo Ochi, M.D., Ph.D.

      Affiliations

    • Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    • Corresponding Author InformationAddress correspondence and reprints request to Mitsuo Ochi, M.D., Department of Orthopaedic Surgery, Hiroshima University, 1-2-3 Kasumi, Minami-ku Hiroshima, Hiroshima 734-8551 Japan.
    • ,
  • Shinobu Yanada, M.Sc.

      Affiliations

    • Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    • ,
  • Masakazu Ishikawa, M.D., Ph.D.

      Affiliations

    • Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    • ,
  • Nobuo Adachi, M.D., Ph.D.

      Affiliations

    • Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    • ,
  • Masataka Deie, M.D., Ph.D.

      Affiliations

    • Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    • ,
  • Koji Arihiro, M.D., Ph.D.

      Affiliations

    • Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.

References 

  1. Murphy JM, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003;48:3464–3474
  2. Nishimori M, Deie M, Kanaya A, Exham H, Adachi N, Ochi M. Repair of chronic osteochondral defects in the rat (A bone marrow-stimulating procedure enhanced by cultured allogenic bone marrow mesenchymal stromal cells). J Bone Joint Surg Br. 2006;88:1236–1244
  3. Wakitani S, Imoto K, Yamamoto T, Saito M, Murata N, Yoneda M. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage. 2002;10:199–206
  4. Tatebe M, Nakamura R, Kagami H, Okada K, Ueda M. Differentiation of transplanted mesenchymal stem cells in a large osteochondral defect in rabbit. Cytotherapy. 2005;7:520–530
  5. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–147
  6. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418:41–49
  7. Ochi M, Adachi N, Nobuto H, Yanada S, Ito Y, Agung M. Articular cartilage repair using tissue engineering technique—Novel approach with minimally invasive procedure. Artif Organs. 2004;28:28–32
  8. Yanada S, Ochi M, Adachi N, Nobuto H, Agung M, Kawamata S. Effects of CD44 antibody– or RGDS peptide–immobilized magnetic beads on cell proliferation and chondrogenesis of mesenchymal stem cells. J Biomed Mater Res A. 2006;77:773–784
  9. Nakashima Y, Deie M, Yanada S, Sharman P, Ochi M. Magnetically labeled human natural killer cells, accumulated in vitro by an external magnetic force, are effective against HOS osteosarcoma cells. Int J Oncol. 2005;27:965–971
  10. Hamasaki T, Tanaka N, Ishida O, et al. Characterization of labeled neural progenitor cells for magnetic targeting. Neuroreport. 2005;16:1641–1645
  11. Bulte JW, Arbab AS, Douglas T, Frank JA. Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Methods Enzymol. 2004;386:275–299
  12. Arbab AS, Yocum GT, Rad AM, et al. Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells. NMR Biomed. 2005;18:553–559
  13. Kostura L, Kraitchman DL, Mackay AM, Pittenger MF, Bulte JW. Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis. NMR Biomed. 2004;17:513–517
  14. Kotobuki N, Hirose M, Takakura Y, Ohgushi H. Cultured autologous human cells for hard tissue regeneration: Preparation and characterization of mesenchymal stem cells from bone marrow. Artif Organs. 2004;28:33–39
  15. Agung M, Ochi M, Yanada S, et al. Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration. Knee Surg Sports Traumatol Arthrosc. 2006;14:1307–1314
  16. Tanaka H, Sugita T, Yasunaga Y, et al. Efficiency of magnetic liposomal transforming growth factor-beta 1 in the repair of articular cartilage defects in a rabbit model. J Biomed Mater Res A. 2005;73:255–263
  17. Daldrup-Link HE, Rudelius M, Piontek G, et al. Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model: In vivo monitoring with 1.5-T MR imaging equipment. Radiology. 2005;234:197–205

 Supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 16209045). The authors report no conflict of interest.

 

Note: To access the supplementary videos accompanying this report, visit the January issue of Arthroscopy at www.arthroscopyjournal.org.

PII: S0749-8063(07)00755-4

doi: 10.1016/j.arthro.2007.08.017

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 24, Issue 1 , Pages 69-76 , January 2008

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