Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 25, Issue 1 , Pages 86-94, January 2009

A Review of Evidence-Based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis

  • C. Thomas Vangsness Jr., M.D.

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to C. Thomas Vangsness Jr., M.D., Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, 1520 San Pablo St, Suite 2000, Los Angeles, CA 90033, U.S.A.
  • ,
  • William Spiker, M.D.
  • ,
  • Juliana Erickson, B.A.

published online 02 October 2008.

Abstract 

The investigation of disease-modifying treatment options for osteoarthritis (OA) has become an important aspect of orthopaedic care. The purpose of this review is to critically evaluate the evidence for the use of glucosamine and chondroitin sulfate for knee OA with the goal of elucidating their indications for clinical use. The published clinical studies of glucosamine and chondroitin sulfate on OA are reviewed within the context of evidence-based medicine. Almost every included trial has found the safety of these compounds to be equal to placebo. In the literature satisfying our inclusion criteria, glucosamine sulfate, glucosamine hydrochloride, and chondroitin sulfate have individually shown inconsistent efficacy in decreasing OA pain and improving joint function. Many studies confirmed OA pain relief with glucosamine and chondroitin sulfate use. The excellent safety profile of glucosamine and chondroitin sulfate therapy should be discussed with patients, and these supplements may serve a role as an initial treatment modality for many OA patients.

Key Words: Glucosamine sulfate, Glucosamine hydrochloride, Chondroitin sulfate, Knee osteoarthritis, Nutritional supplement

 

 The authors report no conflict of interest.

PII: S0749-8063(08)00589-6

doi:10.1016/j.arthro.2008.07.020

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 25, Issue 1 , Pages 86-94, January 2009