Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 25, Issue 11 , Pages 1206-1213 , November 2009

Has Platelet-Rich Plasma Any Role in Anterior Cruciate Ligament Allograft Healing?

  • Juan Ramón Valentí Nin, M.D., Ph.D.

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Clínica Universitaria of Navarra, Pamplona, Spain
    • Corresponding Author InformationAddress correspondence and reprint requests to Juan Ramón Valentí Nin, M.D., Ph.D., Departamento de COT, Clínica Universitaria de Navarra, Avda Pío XII 36, Pamplona CP 31008, Spain
  • ,
  • Gonzalo Mora Gasque, M.D., Ph.D.

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Clínica Universitaria of Navarra, Pamplona, Spain
  • ,
  • Andrés Valentí Azcárate, M.D.

      Affiliations

    • Department of Orthopaedic Surgery and Traumatology, Clínica Universitaria of Navarra, Pamplona, Spain
  • ,
  • Jesús Dámaso Aquerreta Beola, M.D., Ph.D.

      Affiliations

    • Department of Radiology, Clínica Universitaria of Navarra, Pamplona, Spain
  • ,
  • Milagros Hernandez Gonzalez, M.D., Ph.D.

      Affiliations

    • Department of Haematology, Clínica Universitaria of Navarra, Pamplona, Spain

Received 10 October 2008 ,Accepted 2 June 2009.

References 

  1. Rudolph KS, Axel MJ, Buchanan TS, et al. Dynamic stability in the anterior cruciate ligament deficient knee. Knee Surg Sports Traumatol Arthrosc. 2001;9:62–71
  2. Li G, Papannagari R, Defrate LE, et al. The effects of ACL deficiency on mediolateral translation and varus-valgus rotation. Acta Orthop. 2007;78:355–360
  3. Daniel DM, Stone ML, Dobson BE, et al. Fate of the ACL-injured patient: A prospective outcome study. Am J Sports Med. 1994;22:632–644
  4. Mizuta H, Kubota K, Shiraishi M, et al. The conservative treatment of complete tears of the anterior cruciate ligament in skeletally immature patients. J Bone Joint Surg Br. 1995;77:890–894
  5. Andersson C, Odensten M, Good L, et al. Surgical or nonsurgical treatment of acute rupture of the anterior cruciate ligament. J Bone Joint Surg Am. 1989;71:965–974
  6. Andersson C, Odensten M, Gillquist J. Knee function after surgical or nonsurgical treatment of acute rupture of the anterior cruciate ligament: A randomized study with a long-term follow-up period. Clin Orthop Relat Res. 1991;255–263
  7. Linko E, Harilainen A, Malmivaara A, et al. Surgical versus conservative interventions for anterior cruciate ligament ruptures in adults. Cochrane Database Syst Rev. 2005;18:CD001356
  8. McCulloch PC, Lattermann C, Boland AL, et al. An illustrated history of anterior cruciate ligament surgery. J Knee Surg. 2007;20:95–104
  9. Anitua E, Andía I, Ardanza B, et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91:4–15
  10. Mehta S, Watson JT. Platelet rich concentrate: Basic science and current clinical applications. J Orthop Trauma. 2008;22:432–438
  11. Anitua E, Sanchez M, Nurden AT, et al. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24:227–234
  12. Anitua E, Sanchez M, Orive G, et al. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28:4551–4560
  13. Eppley BL, Pietrzak WS, Blanton M. Platelet-rich plasma: A review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006;118:147–159
  14. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:521–528
  15. Tayapongsak P, O'Brien DA, Monteiro CB, et al. Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg. 1994;52:161–165
  16. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: Implications for wound healing. Plast Reconstr Surg. 2004;114:1502–1508
  17. Kevy SV, Jacobson MS. Comparison of methods for point of care preparation of autologous platelet gel. J Extra Corpor Technol. 2004;36:28–35
  18. Sonnleitner D, Huemer P, Sullivan D. A simplified technique for producing platelet-rich plasma and platelet concentrate for intraoral bone grafting techniques: A technical note. Int J Oral Maxillofac Implants. 2000;15:879–882
  19. Mahirogullari M, Yucel O, Huseyin O. Reconstruction of the anterior cruciate ligament using bone-patellar tendon-bone graft with double biodegradable femoral pin fixation. Knee Surg Sports Traumatol Arthrosc. 2006;14:646–653
  20. Hefti F, Mueller W, Jakob RP, et al. Evaluation of the knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc. 1993;1:226–234
  21. McCauley T. MR imaging evaluation of the postoperative knee. Radiology. 2005;234:53–61
  22. Gentili A, Seeger LL, Yao L, et al. Anterior cruciate ligament tear: Indirect signs at MR imaging. Radiology. 1994;193:835–840
  23. Weiler A, Forster C, Hunt P, et al. The influence of locally applied platelet-derived growth factor-BB on free tendon graft remodeling after anterior cruciate ligament reconstruction. Am J Sports Med. 2004;32:881–891
  24. Andrew JG, Hoyland JA, Freemont AJ, et al. Platelet-derived growth factor expression in normally healing human fractures. Bone. 1995;16:455–460
  25. Mehta S, Watson JT. Platelet rich concentrate: Basic science and current clinical applications. J Orthop Trauma. 2008;22:432–438
  26. Hee HT, Majd ME, Holt RT, et al. Do autologous growth factors enhance transforaminal lumbar interbody fusion?. Eur Spine J. 2003;12:400–407
  27. Knighton DR, Ciresi K, Fiegel VD, et al. Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet derived wound healing formula. Surg Gynecol Obstet. 1990;170:56–60
  28. Pietrazk WS, Eppley BL. Platelet rich plasma: Biology and new technology. J Craniofac Surg. 2005;16:1043–1054
  29. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;34:1774–1778
  30. Kleipool AE, Zijl JA, Willems WJ. Arthroscopic ACL reconstruction with bone-patellar tendon-bone allograft or autograft (A prospective study with an average follow up of 4 years). Knee Surg Sports Traumatol Arthrosc. 1998;6:224–230
  31. Harner CD, Olson E, Irrgang JJ, et al. Allograft versus autograft anterior cruciate ligament reconstruction: 3- to 5-year outcome. Clin Orthop Relat Res. 1996;134–144
  32. Chang S, Egami D, Shaieb MD, et al. Anterior cruciate ligament reconstruction: Allograft versus autograft. Arthroscopy. 2003;19:453–462
  33. Busam ML, Rue JP, Bach BR. Fresh-frozen allograft anterior cruciate ligament reconstruction. Clin Sports Med. 2007;26:607–623
  34. Weibrich G, Kleis WK, Hitzler WE, et al. Comparison of the platelet concentrate collection system with the plasma-rich-in-growth factors kit to produce platelet-rich plasma: A technical report. Int J Oral Maxillofac Implants. 2005;20:118–123
  35. Marx RE. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg. 2004;62:489–496

 The authors report no conflict of interest.

PII: S0749-8063(09)00512-X

doi: 10.1016/j.arthro.2009.06.002

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 25, Issue 11 , Pages 1206-1213 , November 2009