Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 26, Issue 11 , Pages 1456-1462 , November 2010

The Effect of Recombinant Human Platelet-Derived Growth Factor BB–Coated Sutures on Rotator Cuff Healing in a Sheep Model

  • Christopher Uggen, M.D.

      Affiliations

    • Kerlan-Jobe Orthopaedic Clinic, Los Angeles, California, U.S.A.
    • Corresponding Author InformationAddress correspondence and reprint requests to Christopher Uggen, M.D., Kalamazoo Orthopaedic Clinic, 2490 S 11th St, Ste 201, Kalamazoo, MI 49009, U.S.A.
    • ,
  • Joshua Dines, M.D.

      Affiliations

    • Hospital For Special Surgery, New York, New York, U.S.A.
    • ,
  • Michelle McGarry, M.S.

      Affiliations

    • Orthopaedic Biomechanics Laboratory, Long Beach, California, U.S.A.
    • ,
  • Daniel Grande, Ph.D.

      Affiliations

    • Long Island Jewish/North Shore Medical Center, New Hyde Park, New York, U.S.A.
    • ,
  • Thay Lee, Ph.D.

      Affiliations

    • Orthopaedic Biomechanics Laboratory, Long Beach, California, U.S.A.
    • ,
  • Orr Limpisvasti, M.D.

      Affiliations

    • Kerlan-Jobe Orthopaedic Clinic, Los Angeles, California, U.S.A.

Received 23 June 2009 ,Accepted 16 February 2010.

References 

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  2. Galatz LM, Ball CM, Teefey SA, Middleton WD, Yamaguchi K. The outcome and repair integrity of completely arthroscopically repaired large and massive rotator cuff tears. J Bone Joint Surg Am. 2004;86:219–224
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  4. Würgler-Hauri CC, Dourte LM, Baradet TC, Williams GR, Soslowsky LJ. Temporal expression of 8 growth factors in tendon-to-bone healing in a rat supraspinatus model. J Shoulder Elbow Surg. 2007;16(Suppl):S198–S203
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  8. Seeherman HJ, Archambault JM, Rodeo SA, et al. rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model. J Bone Joint Surg Am. 2008;90:2206–2219
  9. Uggen JC, Dines J, Uggen CW, et al. Tendon gene therapy modulates the local repair environment in the shoulder. J Am Osteopath Assoc. 2005;105:20–21
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  11. Eriksson A, Nistér M, Leveen P, Westermark B, Heldin CH, Claesson-Welsh L. Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB. J Biol Chem. 1991;266:21138–21144
  12. Millette E, Rauch BH, Kenagy D, Daum G, Clowes AW. Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells. Trends Cardiov Med. 2006;16:25–28
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  15. Chu CC. Degradation and biocompatibility of synthetic absorbable suture materials: General biodegradation phenomena and some factors affecting biodegradation. In:  Hollinger JO editors. Biomedical application of synthetic biodegradable polymers. Boca Raton, FL: CRC Press; 1995;p. 103–128
  16. Dines J, Grande D, ElAttrache N. Biologics in shoulder surgery: Suture augmentation and coating to enhance tendon repair. Tech Orthop. 2007;22:20–25
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 Supported by a grant from The Oxnard Foundation, Oxnard, California. J.D. currently works as a consultant with BioMimetic Therapeutics, Franklin, Tennessee, the manufacturer of recombinant human platelet-derived growth factor BB. The other authors report no conflict of interest.

PII: S0749-8063(10)00194-5

doi: 10.1016/j.arthro.2010.02.025

Arthroscopy: The Journal of Arthroscopic and Related Surgery
Volume 26, Issue 11 , Pages 1456-1462 , November 2010

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