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Intraarticular injection of local anesthetic drugs after arthroscopic knee surgery is used to provide postoperative analgesia. Toxic serum levels of bupivacaine have been reported after its use both in regional anesthesia and for intraarticular injection. The toxicity of the former is related to needle misplacement and the latter is presumed to be absorptive. This study evaluates the effect of tourniquet inflation and the addition of epinephrine on serum concentrations of bupivacaine after intraarticular injection. The result shows that the peak serum bupivacaine concentrations can be reduced by adding epinephrine and injecting it after tourniquet inflation.
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- Monitoring serum bupivacaine levels during arthroscopy.Eur J Clin Pharmacol. 1985; 27: 733-735
- Plasma bupivacaine levels following single dose intraarticular instillation for arthroscopy.Am J Sports Med. 1988; 16: 295-300
- Evaluation of toxicity of local anesthetic agents in man.Br J Anaesth. 1975; 47: 56-60
- Blood levels of bupivacaine after knee arthroscopy of the knee joint.Arthroscopy. 1990; 6: 40-42
- Analysis of mepivacaine, bupivacaine, etidocaine, lidocaine and tetracaine.J Pharmacie. 1980; 69: 603-605
- Residual nerve block following intravenous regional anesthesia.Br J Anaesth. 1974; 46: 668
- Systemic absorption of mepivacaine in commonly used regional block procedures.Anesthesiology. 1972; 37: 277
- Cardiac arrest following regional anesthesia with etidocaine or bupivacaine.Anesthesiology. 1979; 51: 285-287
- Intra-articular absorption of bupivacaine during arthroscopy.Anesthesiology. 1985; 63: A217
- Knee arthroscopy using local anesthetic.Arthroscopy. 1988; 4: 86-87
- Toxic reaction of bupivacaine at low plasma concentration.Anesthesiology. 1984; 61: 99-100
- The pharmacokinetics of bupivacaine when injected intra-articularly after knee arthroscopy.Anesth Analg. 1988; 67: 871-875
© 1992 Arthroscopy Association of North America. Published by Elsevier Inc.