Physicians have known for over 250 years that articular cartilage damage is a “troublesome thing and once destroyed, it is not repaired.”
1Although chondral lesions that penetrate to or through the subchondral bone may fill with fibrocartilage, the biomechanical and biochemical features remain inferior to hyaline cartilage.
- Hunter W.
On the structure and diseases of articulating cartilage.
Philos Trans R Soc Lond B Biol Sci. 1743; 9: 267
- Mandelbaum B.R.
- Browne J.E.
- Fu F.
- Micheli L.
- et al.
Articular cartilage lesions of the knee.
Am J Sports Med. 1998; 26: 853-861
- Mankin H.J.
The response of articular cartilage to mechanical injury.
J Bone Joint Surg Am. 1982; 64: 460-466
4Unlike the recognized poor prognosis of the meniscectomized knee, the natural history of chondral lesions remains far more speculative. At this juncture, treatment recommendations are for those lesions believed to be contributing to a patient’s symptoms and are not generally directed toward asymptomatic lesions. Clinical experience has taught us that after these lesions become symptomatic (a cause of pain, swelling, mechanical symptoms), they tend to persist or inexorably progress over an indeterminate time course.
- Furukawa T.
- Eyre D.R.
- Koide S.
- Glimcher M.J.
Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee.
J Bone Joint Surg Am. 1980; 62: 79-89
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- On the structure and diseases of articulating cartilage.Philos Trans R Soc Lond B Biol Sci. 1743; 9: 267
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- The response of articular cartilage to mechanical injury.J Bone Joint Surg Am. 1982; 64: 460-466
- Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee.J Bone Joint Surg Am. 1980; 62: 79-89
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