Purpose: We tested the hypothesis that the preimplantation mechanical properties of BioCleanse-treated
bone–patellar tendon–bone (BPTB) allografts are not significantly different from those
of untreated specimens. Methods: For this controlled laboratory study, specimens were harvested as central third or
hemi-BPTB units from both knees of 17 cadaveric tissue donors (11 men and 6 women)
aged 19 to 88 years. Donor-matched specimens (20 per group) were randomly assigned
to either BioCleanse-treated or untreated control groups. Specimens were subjected
to 25 minutes of pretensioning at 89 N and then cyclically loaded under longitudinal
tension between 50 N and 250 N for 1,000 cycles at 1 Hz, followed by ramp to failure
at 50 mm/min. Results: No statistically significant difference was found between untreated and BioCleanse-treated
specimens in stiffness (235.3 ± 37.6 N/mm v 222.3 ± 53.4 N/mm, P = .37), cyclic creep (0.38 ± 0.42 mm v 0.40 ± 0.26 mm, P = .81), maximum force (1,685.7 ± 471.6 N v 1,807.0 ± 657.8 N, P = .47), or ultimate stress (29.0 ± 9.8 MPa v 29.0 ± 12.8 MPa, P = .98). Conclusions: The preimplantation mechanical properties of BPTB allografts treated with BioCleanse
are not significantly different from those of untreated controls. Clinical Relevance: This laboratory study compares the biomechanical properties of chemically treated
allografts, which are currently being used in anterior cruciate ligament reconstruction,
with those of nontreated fresh-frozen allografts.
Key Words
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Footnotes
Supported in part by Regeneration Technologies, Alachua, FL.
Mayo Clinic does not endorse the products mentioned in this article.
Note: To access the supplementary tables accompanying this article, visit the April issue of Arthroscopy at www.arthroscopyjournal.org.
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© 2007 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
