Purpose
This prospective, randomized, blinded study was designed to compare the effects of
warmed versus room-temperature levobupivacaine in patients undergoing knee arthroscopy
and partial meniscectomy.
Methods
Patients were randomly allocated into 2 groups of 16 patients each. In all patients
the 2 portal sites were infiltrated with 10 mL of room-temperature mepivacaine (20
mg/mL). In the first group, patients underwent intra-articular injection of 20 mL
of levobupivacaine (5 mg/mL) and 0.005-mg/mL epinephrine (1:200,000) at a temperature
of 40°C ± 0.2°C, whereas in the second group the levobupivacaine and epinephrine were
at room temperature (25°C ± 0.5°C). Pain was graded and recorded intraoperatively
and postoperatively by use of a visual analog scale (VAS). Analgesia was supplemented
if the VAS score was 4 cm or greater with morphine intraoperatively or ketorolac postoperatively.
Results
There were no significant differences between groups in intraoperative and postoperative
VAS values. There was no need for morphine as a rescue dose in any patient during
surgery. Eight patients treated with warmed levobupivacaine and seven patients treated
with room-temperature levobupivacaine requested a single rescue dose of ketorolac
(30 mg) postoperatively.
Conclusions
No compelling evidence exists to suggest that intra-articular injection of warmed
levobupivacaine is more effective than room-temperature levobupivacaine for intraoperative
anesthesia and postoperative analgesia in patients undergoing partial meniscectomy
during knee arthroscopy.
Level of Evidence
Level I, randomized controlled trial.
Key Words
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References
- Local anesthesia for knee arthroscopy.Am J Sports Med. 1995; 23: 50-53
- Can local anesthesia be recommended for routine use in elective knee arthroscopy?.Arthroscopy. 2000; 16: 183-190
- Warm steaming enhances the topical anesthetic effect of lidocaine.Anesth Analg. 2004; 98: 982-985
- Latency of brachial plexus block.Anaesthesia. 1990; 45: 297-301
- Intra-articular injection of warmed lidocaine improves intraoperative anaesthetic and postoperative analgesic conditions.Br J Anaesth. 2006; 96: 259-261
- The relative motor blocking potencies of bupivacaine and levobupivacaine in labor.Anesth Analg. 2003; 97: 1509-1513
- Chondrolysis after continuous intra-articular bupivacaine infusion: An experimental model investigating chondrotoxicity in the rabbit shoulder.Arthroscopy. 2006; 22: 813-819
- Bupivacaine, levobupivacaine and ropivacaine: Are they clinically different?.J Clin Anesth. 2005; 19: 247-268
- Serum lidocaine levels during arthroscopy using continuous irrigation with lidocaine.Clin Orthop Relat Res. 1988; : 182-184
- Analgesics: Ion channel ligands/sodium channel blockers/local anesthetics.in: Evers A.S. Maze M. Anesthetic pharmacology. Churchill Livingstone, Philadelphia2004: 507-535
- The influence of hyperbaric bupivacaine temperature on the spread of spinal anesthesia.Anesth Analg. 2006; 102: 272-275
- Intra-articular ropivacaine injection does not alleviate pain after day-case knee arthroscopy performed under spinal anaesthesia.Ann Chir Gynaecol. 2001; 90: 47-50
- A systemic review of intra-articular local anesthesia for postoperative pain relief after arthroscopic knee surgery.Reg Anesth Pain Med. 1999; 24: 430-437
- The postoperative analgesic effects of intra-articular levobupivacaine in elective day-case arthroscopy of knee: A prospective, randomized, double-blind clinical study.Knee Surg Sports Traumatol Arthrosc. 2006; 14: 120-124
- Intra-articular sufentanil in multimodal analgesic management after arthroscopic anterior cruciate ligament reconstruction: A prospective, randomized double-blinded study.Arthroscopy. 2008; 24: 909-913
- Intraarticular tramadol-bupivacaine combination prolongs the duration of postoperative analgesia after outpatient arthroscopic knee surgery.Anesth Analg. 2008; 107: 292-299
- Intraarticular tramadol plus pericapsular incisional bupivacaine provides better analgesia than intraarticular plus pericapsular incisional bupivacaine after outpatient arthroscopic meniscectomy.Knee Surg Sports Traumatol Arthrosc. 2007; 15: 564-568
- Long-term effects of bupivacaine on cartilage in a rabbit shoulder model.Am J Sports Med. 2009; 37: 72-77
- Bupivacaine and saline effects on articular cartilage.Arthroscopy. 1985; 1: 123-127
- The efficacy of continuous bupivacaine infiltration following arthroscopic rotator cuff repair.Arthroscopy. 2008; 24: 397-402
- Postoperative analgesic efficacy of peripheral levobupivacaine and ropivacaine: A prospective randomized double-blind trial in patients after total knee arthroscopy.Anesth Analg. 2008; 106: 1559-1560
- Comparison of two delivery methods of local anesthetic distribution after intra-articular knee injection.Orthopedics. 2006; 29: 439-442
- Stability of lidocaine in aqueous solution: Effect of temperature, pH, buffer, and metal ions on amide hydrolysis.Pharm Res. 1987; 4: 42-45
- Effect of alkalinization of lidocaine on median nerve block.Br J Anaesth. 2000; 84: 163-168
- Effect of temperature and pH of bupivacaine for intradermal anesthesia.Am J Emerg Med. 1998; 16: 117-120
- A simple technique to make bupivacaine a rapid-acting epidural anesthetic.Reg Anesth. 1987; 12: 135-138
- Density of spinal anaesthetic solutions of bupivacaine, levobupivacaine, and ropivacaine with and without dextrose.Br J Anaesth. 2004; 92: 547-551
- Dissociation constants of local anesthetics and their temperature dependence.Anesth Analg. 1983; 62: 1025-1030
- Comparison of S(-)bupivacaine with racemic (RS)-bupivacaine in supraclavicular brachial plexus block.Br J Anaesth. 1998; 80: 594-598
- Efficacy of intra-articular bupivacaine, ropivacaine, or a combination of ropivacaine, morphine, and ketorolac on postoperative pain relief after ambulatory arthroscopic knee surgery: A randomized double-blind study.Reg Anesth Pain Med. 2006; 31: 26-33
Article info
Publication history
Accepted:
March 21,
2009
Received:
October 14,
2008
Footnotes
The authors report no conflict of interest.
Identification
Copyright
© 2009 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.