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Letter to the Editor Regarding Our Article “Properties of Biologic Scaffolds and Their Response to Mesenchymal Stem Cells”

      To the Editor:
      We are writing in regard to our article “Properties of Biologic Scaffolds and Their Response to Mesenchymal Stem Cells” published in the March 2014 issue of Arthroscopy.
      • Beitzel K.
      • McCarthy M.B.
      • Cote M.P.
      • et al.
      Properties of biologic scaffolds and their response to mesenchymal stem cells.
      Throughout the article, we refer to the 2 collagen scaffolds tested as being “highly and non–cross-linked.” These terms were meant to describe the histologic structure of the scaffold; they were not meant to indicate anything else, such as the chemical processes by which some biologic scaffolds are manufactured.
      • Badylak S.F.
      • Freytes D.O.
      • Gilbert T.W.
      Extracellular matrix as a biological scaffold material: Structure and function.
      In our study the porcine collagen scaffold has a loose fibrous infrastructure compared with the human dermal scaffold that is more tightly packed.
      We have received feedback from clinicians that this nomenclature could be misleading, and this was not our intent. The purpose of our study was to accurately report the response of mesenchymal stem cells to different biologic scaffolds and not compare the structure of the grafts. Our only intent in using this terminology was as a way to differentiate between grafts.
      Furthermore, in the “Discussion” section, “Flexigraft” was written in error; it should have said “Arthroflex.” We apologize if there has been any confusion about this terminology, and we sincerely hope that we have cleared up any misunderstandings.

      References

        • Beitzel K.
        • McCarthy M.B.
        • Cote M.P.
        • et al.
        Properties of biologic scaffolds and their response to mesenchymal stem cells.
        Arthroscopy. 2014; 30: 289-298
        • Badylak S.F.
        • Freytes D.O.
        • Gilbert T.W.
        Extracellular matrix as a biological scaffold material: Structure and function.
        Acta Biomater. 2009; 5: 1-13

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