Efficacy and Safety of Plasma Rich in Growth Factors Intra-Articular Infiltrations in the Treatment of Knee Osteoarthritis

References

1. • Felson D.T.
   Developments in the clinical understanding of osteoarthritis.
   Arthritis Res Ther. 2009; 11: 203
   View in Article

   • Google Scholar
2. • Goldring M.B.
   • Marcu K.B.
   Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis.
   Trends Mol Med. 2012; 18: 109-118
   View in Article

   • Google Scholar
3. • Sandell L.J.
   Etiology of osteoarthritis: Genetics and synovial joint development.
   Nat Rev Rheumatol. 2012; 8: 77-89
   View in Article

   • Google Scholar
4. • Pereira D.
   • Peleteiro B.
   • Araujo J.
   • Branco J.
   • Santos R.A.
   • Ramos E.
   The effect of osteoarthritis definition on prevalence and incidence estimates: A systematic review.
   Osteoarthritis Cartilage. 2011; 19: 1270-1285
   View in Article

   • Google Scholar
5. • Wielage R.C.
   • Myers J.A.
   • Klein R.W.
   • Happich M.
   Cost-effectiveness analyses of osteoarthritis oral therapies: A systematic review.
   Appl Health Econ Health Policy. 2013; 11: 593-618
   View in Article

   • Google Scholar
6. • Hiligsmann M.
   • Cooper C.
   • Arden N.
   • et al.
   Health economics in the field of osteoarthritis: An expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
   Semin Arthritis Rheum. 2013; 43: 303-313
   View in Article

   • Google Scholar

7. Filardo G, Kon E, Roffi A, Di Matteo B, Merli ML, Marcacci M. Platelet-rich plasma: Why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surg Sports Traumatol Arthrosc in press, available online 26 November, 2013. http//dx.doi.org/10.1007/s00167-013-2743-1.

   View in Article

   • Google Scholar
8. • Smyth N.A.
   • Murawski C.D.
   • Fortier L.A.
   • Cole B.J.
   • Kennedy J.G.
   Platelet-rich plasma in the pathologic processes of cartilage: Review of basic science evidence.
   Arthroscopy. 2013; 29: 1399-1409
   View in Article

   • Google Scholar
9. • Zhu Y.
   • Yuan M.
   • Meng H.Y.
   • et al.
   Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: A review.
   Osteoarthritis Cartilage. 2013; 21: 1627-1637
   View in Article

   • Google Scholar
10. • Anitua E.
    • Sánchez M.
    • Orive G.
    • Padilla S.
    A biological therapy to osteoarthritis treatment using platelet-rich plasma.
    Expert Opin Biol Ther. 2013; 13: 1161-1172
    View in Article

    • Google Scholar
11. • Anitua E.
    • Prado R.
    • Sánchez M.
    • Orive G.
    Platelet-rich plasma: Preparation and formulation.
    Oper Tech Orthop. 2012; 22: 25-32
    View in Article

    • Google Scholar
12. • Dohan Ehrenfest D.M.
    • Rasmusson L.
    • Albrektsson T.
    Classification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).
    Trends Biotechnol. 2009; 27: 158-167
    View in Article

    • Google Scholar
13. • Mishra A.
    • Harmon K.
    • Woodall J.
    • Vieira A.
    Sports medicine applications of platelet rich plasma.
    Curr Pharm Biotechnol. 2012; 13: 1185-1195
    View in Article

    • Google Scholar
14. • DeLong J.M.
    • Russell R.P.
    • Mazzocca A.D.
    Platelet-rich plasma: The PAW classification system.
    Arthroscopy. 2012; 28: 998-1009
    View in Article

    • Google Scholar
15. • Chahal J.
    • Van Thiel G.S.
    • Mall N.
    • et al.
    The role of platelet-rich plasma in arthroscopic rotator cuff repair: A systematic review with quantitative synthesis.
    Arthroscopy. 2012; 28: 1718-1727
    View in Article

    • Google Scholar
16. • Sheth U.
    • Simunovic N.
    • Klein G.
    • et al.
    Efficacy of autologous platelet-rich plasma use for orthopaedic indications: A meta-analysis.
    J Bone Joint Surg Am. 2012; 94: 298-307
    View in Article

    • Google Scholar
17. • Liberati A.
    • Altman D.G.
    • Tetzlaff J.
    • et al.
    The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration.
    BMJ. 2009; 339: b2700
    View in Article

    • Google Scholar
18. • Moher D.
    • Liberati A.
    • Tetzlaff J.
    • Altman D.G.
    • Group P.
    Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement.
    PLoS Med. 2009; 6: e1000097
    View in Article

    • Google Scholar
19. • Altman R.
    • Asch E.
    • Bloch D.
    • et al.
    Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association.
    Arthritis Rheum. 1986; 29: 1039-1049
    View in Article

    • Google Scholar
20. • Higgins J.P.
    • Altman D.G.
    • Gotzsche P.C.
    • et al.
    The Cochrane Collaboration's tool for assessing risk of bias in randomised trials.
    BMJ. 2011; 343: d5928
    View in Article

    • Google Scholar
21. • Atkins D.
    • Best D.
    • Briss P.A.
    • et al.
    Grading quality of evidence and strength of recommendations.
    BMJ. 2004; 328: 1490
    View in Article

    • Google Scholar
22. • Guyatt G.H.
    • Oxman A.D.
    • Vist G.E.
    • et al.
    GRADE: An emerging consensus on rating quality of evidence and strength of recommendations.
    BMJ. 2008; 336: 924-926
    View in Article

    • Google Scholar
23. • Jang S.J.
    • Kim J.D.
    • Cha S.S.
    Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis.
    Eur J Orthop Surg Traumatol. 2013; 23: 573-580
    View in Article

    • Google Scholar
24. • Cerza F.
    • Carni S.
    • Carcangiu A.
    • et al.
    Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis.
    Am J Sports Med. 2012; 40: 2822-2827
    View in Article

    • Google Scholar
25. • Filardo G.
    • Kon E.
    • Di Martino A.
    • et al.
    Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: Study design and preliminary results of a randomized controlled trial.
    BMC Musculoskelet Disord. 2012; 13: 229
    View in Article

    • Google Scholar
26. • Darabos N.
    • Haspl M.
    • Moser C.
    • Darabos A.
    • Bartolek D.
    • Groenemeyer D.
    Intraarticular application of autologous conditioned serum (ACS) reduces bone tunnel widening after ACL reconstructive surgery in a randomized controlled trial.
    Knee Surg Sports Traumatol Arthrosc. 2011; 19: S36-S46
    View in Article

    • Google Scholar
27. • Kon E.
    • Buda R.
    • Filardo G.
    • et al.
    Platelet-rich plasma: Intra-articular knee injections produced favorable results on degenerative cartilage lesions.
    Knee Surg Sports Traumatol Arthrosc. 2010; 18: 472-479
    View in Article

    • Google Scholar
28. • Gobbi A.
    • Karnatzikos G.
    • Mahajan V.
    • Malchira S.
    Platelet-rich plasma treatment in symptomatic patients with knee osteoarthritis: Preliminary results in a group of active patients.
    Sports Health. 2012; 4: 162-172
    View in Article

    • Google Scholar
29. • Kon E.
    • Mandelbaum B.
    • Buda R.
    • et al.
    Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: From early degeneration to osteoarthritis.
    Arthroscopy. 2011; 27: 1490-1501
    View in Article

    • Google Scholar
30. • Sampson S.
    • Reed M.
    • Silvers H.
    • Meng M.
    • Mandelbaum B.
    Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: A pilot study.
    Am J Phys Med Rehabil. 2010; 89: 961-969
    View in Article

    • Google Scholar
31. • Patel S.
    • Dhillon M.S.
    • Aggarwal S.
    • Marwaha N.
    • Jain A.
    Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: A prospective, double-blind, randomized trial.
    Am J Sports Med. 2013; 41: 356-364
    View in Article

    • Google Scholar
32. • Spakova T.
    • Rosocha J.
    • Lacko M.
    • Harvanova D.
    • Gharaibeh A.
    Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid.
    Am J Phys Med Rehabil. 2012; 91: 411-417
    View in Article

    • Google Scholar
33. • Wang-Saegusa A.
    • Cugat R.
    • Ares O.
    • Seijas R.
    • Cusco X.
    • Garcia-Balletbo M.
    Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life.
    Arch Orthop Trauma Surg. 2011; 131: 311-317
    View in Article

    • Google Scholar
34. • Filardo G.
    • Kon E.
    • Pereira Ruiz M.T.
    • et al.
    Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: Single- versus double-spinning approach.
    Knee Surg Sports Traumatol Arthrosc. 2012; 20: 2082-2091
    View in Article

    • Google Scholar
35. • Sánchez M.
    • Anitua E.
    • Azofra J.
    • Aguirre J.J.
    • Andia I.
    Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: A retrospective cohort study.
    Clin Exp Rheumatol. 2008; 26: 910-913
    View in Article

    • Google Scholar
36. • Sánchez M.
    • Fiz N.
    • Azofra J.
    • et al.
    A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis.
    Arthroscopy. 2012; 28: 1070-1078
    View in Article

    • Google Scholar
37. • Say F.
    • Gurler D.
    • Yener K.
    • Bulbul M.
    • Malkoc M.
    Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis.
    Acta Chir Orthop Traumatol Cech. 2013; 80: 278-283
    View in Article

    • Google Scholar
38. • Vaquerizo V.
    • Plasencia M.A.
    • Arribas I.
    • et al.
    Comparison of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) versus Durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: A randomized controlled trial.
    Arthroscopy. 2013; 29: 1635-1643
    View in Article

    • Google Scholar
39. • Khoshbin A.
    • Leroux T.
    • Wasserstein D.
    • et al.
    The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: A systematic review with quantitative synthesis.
    Arthroscopy. 2013; 29: 2037-2048
    View in Article

    • Google Scholar
40. • Chang K.V.
    • Hung C.Y.
    • Aliwarga F.
    • Wang T.G.
    • Han D.S.
    • Chen W.S.
    Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: A systematic review and meta-analysis.
    Arch Phys Med Rehabil. 2014; 95: 562-575
    View in Article

    • Scopus (158)
    • Abstract
    • Full Text
    • Full Text PDF
    • Google Scholar
41. • Dold A.P.
    • Zywiel M.G.
    • Taylor D.W.
    • Dwyer T.
    • Theodoropoulos J.
    Platelet-rich plasma in the management of articular cartilage pathology: A systematic review.
    Clin J Sport Med. 2014; 24: 31-43
    View in Article

    • Google Scholar
42. • Coombes B.K.
    • Bisset L.
    • Vicenzino B.
    Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: A systematic review of randomised controlled trials.
    Lancet. 2010; 376: 1751-1767
    View in Article

    • Google Scholar
43. • de Vos R.J.
    • van Veldhoven P.L.
    • Moen M.H.
    • Weir A.
    • Tol J.L.
    • Maffulli N.
    Autologous growth factor injections in chronic tendinopathy: A systematic review.
    Br Med Bull. 2010; 95: 63-77
    View in Article

    • Google Scholar
44. • Taylor D.W.
    • Petrera M.
    • Hendry M.
    • Theodoropoulos J.S.
    A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries.
    Clin J Sport Med. 2011; 21: 344-352
    View in Article

    • Google Scholar
45. • Vavken P.
    • Sadoghi P.
    • Murray M.M.
    The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: A systematic review of controlled trials.
    Arthroscopy. 2011; 27: 1573-1583
    View in Article

    • Google Scholar
46. • Ahmad Z.
    • Brooks R.
    • Kang S.N.
    • et al.
    The effect of platelet-rich plasma on clinical outcomes in lateral epicondylitis.
    Arthroscopy. 2013; 29: 1851-1862
    View in Article

    • Google Scholar
47. • de Vos R.J.
    • Windt J.
    • Weir A.
    Strong evidence against platelet-rich plasma injections for chronic lateral epicondylar tendinopathy: A systematic review.
    Br J Sports Med. 2014; 48: 952-956
    View in Article

    • Google Scholar
48. • Hamid M.S.
    • Yusof A.
    Mohamed Ali MR. Platelet-rich plasma (PRP) for acute muscle injury: A systematic review.
    PLoS One. 2014; 9: e90538
    View in Article

    • Google Scholar
49. • Vannini F.
    • Di Matteo B.
    • Filardo G.
    • Kon E.
    • Marcacci M.
    • Giannini S.
    Platelet-rich plasma for foot and ankle pathologies: A systematic review.
    Foot Ankle Surg. 2014; 20: 2-9
    View in Article

    • Google Scholar

50. Anitua E, Sánchez M, Prado R, Orive G. The type of platelet-rich plasma may influence the safety of the approach. Knee Surg Sports Traumatol Arthrosc in press, available online 9 May, 2012. http://dx.doi.org/10.1007/s00167-012-2043-1.

    View in Article

    • Google Scholar
51. • McCarrel T.M.
    • Minas T.
    • Fortier L.A.
    Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy.
    J Bone Joint Surg Am. 2012; 94: e1431-e1438
    View in Article

    • Google Scholar
52. • Sundman E.A.
    • Cole B.J.
    • Fortier L.A.
    Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma.
    Am J Sports Med. 2011; 39: 2135-2140
    View in Article

    • Google Scholar
53. • Andia I.
    • Maffulli N.
    Platelet-rich plasma for managing pain and inflammation in osteoarthritis.
    Nat Rev Rheumatol. 2013; 9: 721-730
    View in Article

    • Google Scholar
54. • Descalzi F.
    • Ulivi V.
    • Cancedda R.
    • et al.
    Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism.
    Tissue Eng Part A. 2013; 19: 2120-2129
    View in Article

    • Google Scholar
55. • Andia I.
    • Abate M.
    Knee osteoarthritis: Hyaluronic acid, platelet-rich plasma or both in association?.
    Expert Opin Biol Ther. 2014; 14: 635-649
    View in Article

    • Google Scholar
56. • Bannuru R.R.
    • Natov N.S.
    • Dasi U.R.
    • Schmid C.H.
    • McAlindon T.E.
    Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis—Meta-analysis.
    Osteoarthritis Cartilage. 2011; 19: 611-619
    View in Article

    • Google Scholar
57. • Bellamy N.
    • Campbell J.
    • Robinson V.
    • Gee T.
    • Bourne R.
    • Wells G.
    Viscosupplementation for the treatment of osteoarthritis of the knee.
    Cochrane Database Syst Rev. 2006; : CD005321
    View in Article

    • Google Scholar
58. • Filardo G.
    • Kon E.
    • Buda R.
    • et al.
    Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis.
    Knee Surg Sports Traumatol Arthrosc. 2011; 19: 528-535
    View in Article

    • Google Scholar