Purpose
To determine the degradation and performance outcomes of poly(lactide-co-glycolide)/β-tricalcium phosphate (PLGA/β-TCP) implants.
Methods
A MEDLINE and Embase search for randomized or nonrandomized controlled studies and
prospective or retrospective case series that used biocomposite interference screws
or suture anchors composed of PLGA/β-TCP was performed. Main outcomes included volume
of implant resorption and incidence of osteoconductivity at implant sites, imaging
findings, adverse events, and the frequency of reoperations.
Results
A total of 13 studies representing 668 patients with either knee or shoulder implants
were included. Median follow-up was 28 months (range: 12-37 months). Biocomposite
implants lost 88% of their original volume during follow-up. Osteoconductivity at
the implant site was identified in 63% of cases. Adverse events included tunnel widening
(3%), effusion (5%), and cyst formation (4%). Synovitis was not reported.
Conclusions
Biocomposite interference screws or suture anchors composed of PLGA/β-TCP almost fully
absorb over 3 years while promoting osteoconductivity with few reported adverse events.
Level of Evidence
Level IV, systematic review of Level I-IV studies.
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Article Info
Publication History
Published online: December 17, 2016
Accepted:
September 28,
2016
Received:
March 3,
2016
Footnotes
The authors report the following potential conflicts of interest or sources of funding: F.A.B. receives support from DePuy-Mitek, Linvatec (consultancy fees); institutional grant from the F. Alan Barber MD FACS Research Fund; DePuy-Mitek, Arthrex (patents); DePuy-Mitek (royalties); Johnson & Johnson (stock); DePuy-Mitek, Linvatec (travel expenses). D.B.S. is an employee of DePuy Synthes Mitek Sports Medicine, and has stocks/stock options from DePuy-Mitek. S.B. is an employee of DePuy Synthes Mitek Sports Medicine, and has stock/stock options from DePuy-Mitek. L.E.M. receives support from DePuy Synthes Mitek Sports Medicine (fees to institution for participation in review activities such as data monitoring boards, statistical analysis, end-point committees, and the like).
Identification
Copyright
© 2016 by the Arthroscopy Association of North America
