Invention Versus Gold Standard: A Hands-On Research Pearl on Study Design and Statistical Concerns

Published:November 07, 2018DOI:


      This article points out what is important to consider when planning to perform and analyze a commonly seen study involving a comparison of an innovation with something established. A hands-on guide on how to perform this type of research trial and how to choose proper statistical methods is given.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Arthroscopy
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Karikis I.
        • Ejerhed L.
        • Sernert N.
        • Rostgard-Christensen L.
        • Kartus J.
        Radiographic tibial tunnel assessment after anterior cruciate ligament reconstruction using hamstring tendon autografts and biocomposite screws: A prospective study with 5-year follow-up.
        Arthroscopy. 2017; 33: 2184-2194
        • Laxdal G.
        • Kartus J.
        • Eriksson B.I.
        • Faxen E.
        • Sernert N.
        • Karlsson J.
        Biodegradable and metallic interference screws in anterior cruciate ligament reconstruction surgery using hamstring tendon grafts: Prospective randomized study of radiographic results and clinical outcome.
        Am J Sports Med. 2006; 34: 1574-1580
        • Harris J.D.
        • Brand J.C.
        • Cote M.P.
        • Faucett S.C.
        • Dhawan A.
        Research pearls: The significance of statistics and perils of pooling. Part 1: Clinical versus statistical significance.
        Arthroscopy. 2017; 33: 1102-1112
        • Levy D.M.
        • Kuhns B.D.
        • Chahal J.
        • Philippon M.J.
        • Kelly B.T.
        • Nho S.J.
        Hip arthroscopy outcomes with respect to patient acceptable symptomatic state and minimal clinically important difference.
        Arthroscopy. 2016; 32: 1877-1886
        • Altman D.G.
        • Bland J.M.
        Statistics notes: The normal distribution.
        BMJ. 1995; 310: 298