Advertisement
Systematic Review| Volume 37, ISSUE 2, P771-781, February 2021

Download started.

Ok

Diagnostic Performance of Artificial Intelligence for Detection of Anterior Cruciate Ligament and Meniscus Tears: A Systematic Review

Published:September 18, 2020DOI:https://doi.org/10.1016/j.arthro.2020.09.012

      Purpose

      To (1) determine the diagnostic efficacy of artificial intelligence (AI) methods for detecting anterior cruciate ligament (ACL) and meniscus tears and to (2) compare the efficacy to human clinical experts.

      Methods

      PubMed, OVID/Medline, and Cochrane libraries were queried in November 2019 for research articles pertaining to AI use for detection of ACL and meniscus tears. Information regarding AI model, prediction accuracy/area under the curve (AUC), sample sizes of testing/training sets, and imaging modalities were recorded.

      Results

      A total of 11 AI studies were identified: 5 investigated ACL tears, 5 investigated meniscal tears, and 1 investigated both. The AUC of AI models for detecting ACL tears ranged from 0.895 to 0.980, and the prediction accuracy ranged from 86.7% to 100%. Of these studies, 3 compared AI models to clinical experts. Two found no significant differences in diagnostic capability, whereas one found that radiologists had a significantly greater sensitivity for detecting ACL tears (P = .002) and statistically similar specificity and accuracy. Of the 5 studies investigating the meniscus, the AUC for AI models ranged from 0.847 to 0.910 and prediction accuracy ranged from 75.0% to 90.0%. Of these studies, 2 compared AI models with clinical experts. One found no significant differences in diagnostic accuracy, whereas one found that the AI model had a significantly lower specificity (P = .003) and accuracy (P = .015) than radiologists. Two studies reported that the addition of AI models significantly increased the diagnostic performance of clinicians compared to their efforts without these models.

      Conclusions

      AI prediction capabilities were excellent and may enhance the diagnosis of ACL and meniscal pathology; however, AI did not outperform clinical experts.

      Clinical Relevance

      AI models promise to improve diagnosing certain pathologies as well as or better than human experts, are excellent for detecting ACL and meniscus tears, and may enhance the diagnostic capabilities of human experts; however, when compared with these experts, they may not offer any significant advantage.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Arthroscopy
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bini S.A.
        Artificial intelligence, machine learning, deep learning, and cognitive computing: What do these terms mean and how will they impact health care?.
        J Arthroplasty. 2018; 33: 2358-2361
        • Helm J.M.
        • Swiergosz A.M.
        • Haeberle H.S.
        • et al.
        Machine learning and artificial intelligence: Definitions, applications, and future directions.
        Curr Rev Musculoskelet Med. 2020; 13: 69-76
        • Kunze K.N.
        • Karhade A.V.
        • Sadauskas A.J.
        • Schwab J.H.
        • Levine B.R.
        Development of machine learning algorithms to predict clinically meaningful improvement for the patient-reported health state after total hip arthroplasty.
        J Arthroplasty. 2020; 35: 2119-2123
        • Karhade A.V.
        • Ahmed A.K.
        • Pennington Z.
        • et al.
        External validation of the SORG 90-day and 1-year machine learning algorithms for survival in spinal metastatic disease.
        Spine J. 2020; 20: 14-21
        • Karhade A.V.
        • Schwab J.H.
        • Bedair H.S.
        Development of machine learning algorithms for prediction of sustained postoperative opioid prescriptions after total hip arthroplasty.
        J Arthroplasty. 2019; 34: 2272-2277.e2271
        • Karhade A.V.
        • Shah A.A.
        • Bono C.M.
        • et al.
        Development of machine learning algorithms for prediction of mortality in spinal epidural abscess.
        Spine J. 2019; 19: 1950-1959
        • Ogunyemi O.
        • Kermah D.
        Machine learning approaches for detecting diabetic retinopathy from clinical and public health records.
        AMIA Annu Symp Proc. 2015; 2015: 983-990
        • Gulshan V.
        • Peng L.
        • Coram M.
        • et al.
        Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs.
        JAMA. 2016; 316: 2402-2410
        • Esteva A.
        • Kuprel B.
        • Novoa R.A.
        • et al.
        Dermatologist-level classification of skin cancer with deep neural networks.
        Nature. 2017; 542: 115-118
        • Thio Q.
        • Karhade A.V.
        • Ogink P.T.
        • et al.
        Development and internal validation of machine learning algorithms for preoperative survival prediction of extremity metastatic disease.
        Clin Orthop Relat Res. 2020; 478: 322-333
        • Thio Q.
        • Karhade A.V.
        • Ogink P.T.
        • et al.
        Can machine-learning techniques be used for 5-year survival prediction of patients with chondrosarcoma?.
        Clin Orthop Relat Res. 2018; 476: 2040-2048
        • Langerhuizen D.W.G.
        • Janssen S.J.
        • Mallee W.H.
        • et al.
        What are the applications and limitations of artificial intelligence for fracture detection and classification in orthopaedic trauma imaging? A systematic review.
        Clin Orthop Relat Res. 2019; 477: 2482-2491
        • Moher D.
        • Liberati A.
        • Tetzlaff J.
        • Altman D.G.
        • Group P.
        Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement.
        BMJ. 2009; 339: b2535
        • Harris J.D.
        • Quatman C.E.
        • Manring M.M.
        • Siston R.A.
        • Flanigan D.C.
        How to write a systematic review.
        Am J Sports Med. 2014; 42: 2761-2768
        • Abdullah A.A.
        • Azz-Zahra N.S.F.
        Design of an intelligent diagnostic system for detection of knee injuries.
        Appl Mech Mater. 2013; 339: 219-224
        • Bien N.
        • Rajpurkar P.
        • Ball R.L.
        • et al.
        Deep-learning-assisted diagnosis for knee magnetic resonance imaging: Development and retrospective validation of MRNet.
        PLoS Med. 2018; 15e1002699
        • Chang P.D.
        • Wong T.T.
        • Rasiej M.J.
        Deep learning for detection of complete anterior cruciate ligament tear.
        J Digit Imaging. 2019; 32: 980-986
        • Couteaux V.
        • Si-Mohamed S.
        • Nempont O.
        • et al.
        Automatic knee meniscus tear detection and orientation classification with Mask-RCNN.
        Diagn Interv Imaging. 2019; 100: 235-242
        • Fu J.L.C.
        • Wang C.
        • Ou Y.
        Computer-aided diagnosis for knee meniscus tears in magnetic resonance imaging.
        J Indust Prod Engin. 2013; 30: 67-77
        • Liu F.G.B.
        • Zhou Z.
        • Samsonov A.
        • et al.
        Fully Automated diagnosis of anterior cruciate ligament tears on knee mr images by using deep learning.
        Radiol Artif Intell. 2019; 1: 180091
        • Mazlan S.S.
        • Ayob M.
        • Bakti Z.
        Anterior cruciate ligament (ACL) Injury classification system using support vector machine (SVM).
        Proc Int Engin Tech. 2017; : 1-5
        • Pedoia V.
        • Norman B.
        • Mehany S.N.
        • Bucknor M.D.
        • Link T.M.
        • Majumdar S.
        3D convolutional neural networks for detection and severity staging of meniscus and PFJ cartilage morphological degenerative changes in osteoarthritis and anterior cruciate ligament subjects.
        J Magn Reson Imaging. 2019; 49: 400-410
        • Roblot V.
        • Giret Y.
        • Bou Antoun M.
        • et al.
        Artificial intelligence to diagnose meniscus tears on MRI.
        Diagn Interv Imaging. 2019; 100: 243-249
        • Štadjuhar I.
        • Mamula M.
        • Miletic D.
        • Unal G.
        Semi-automated detection of anterior cruciate ligament injury from MRI.
        Comput Methods Programs Biomed. 2017; 140: 151-164
        • Fazel Zarandi M.H.
        • Khadangi A.
        • Karimi F.
        • Turksen I.B.
        A computer-aided type-II Fuzzy image processing for diagnosis of meniscus tear.
        J Digit Imaging. 2016; 29: 677-695
        • Cook N.R.
        Use and misuse of the receiver operating characteristic curve in risk prediction.
        Circulation. 2007; 115: 928-935
        • Senders J.T.
        • Arnaout O.
        • Karhade A.V.
        • et al.
        Natural and artificial intelligence in neurosurgery: A systematic review.
        Neurosurgery. 2018; 83: 181-192
        • Nam J.G.
        • Park S.
        • Hwang E.J.
        • et al.
        Development and validation of deep learning-based automatic detection algorithm for malignant pulmonary nodules on chest radiographs.
        Radiology. 2019; 290: 218-228
        • Lindsey R.
        • Daluiski A.
        • Chopra S.
        • et al.
        Deep neural network improves fracture detection by clinicians.
        Proc Natl Acad Sci USA. 2018; 115: 11591-11596
        • Topol E.J.
        High-performance medicine: The convergence of human and artificial intelligence.
        Nat Med. 2019; 25: 44-56
      1. Gale W, Oakden-Rayner L, Carneiro G, Bradley AP, Palmer LJ. Detecting hip fractures with radiologist-level performance using deep neural networks arXiv: Computer Vision and Pattern Recognition 2017. Volume abs/1711.06504

        • Lee H.
        • Yune S.
        • Mansouri M.
        • et al.
        An explainable deep-learning algorithm for the detection of acute intracranial haemorrhage from small datasets.
        Nat Biomed Eng. 2019; 3: 173-182
        • Collins G.S.
        • Moons K.G.M.
        Reporting of artificial intelligence prediction models.
        Lancet. 2019; 393: 1577-1579
        • Ozenne B.
        • Subtil F.
        • Maucort-Boulch D.
        The precision–recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases.
        J Clin Epidemiol. 2015; 68: 855-859
        • Brier G.W.
        Verification of forecasts expressed in terms of probability.
        Monthly Weather Rev. 1950; 78: 1-3
        • Ramkumar P.N.
        • Kunze K.N.
        • Haeberle H.S.
        • et al.
        Clinical and research medical applications of artificial intelligence: Fundamentals for the orthopaedic surgeon.
        Arthroscopy. 2020; (pii: S0749-8063(20)30687-3. doi:10.1016/j.arthro.2020.08.009.)