Purpose
To analyze the effect of patient age, sex, and associated preoperative factors on
patient-reported outcome (PRO) measures and graft survival following primary meniscal
allograft transplantation (MAT).
Methods
A prospectively collected database was retrospectively reviewed to identify patients
who underwent primary MAT with a minimum of 2 years of follow up between 1999 and
2017. Demographic, intraoperative, and postoperative outcome data were collected for
each patient. Postoperative outcomes were stratified based on age and sex, and comparative
statistical analysis was performed between sexes, both >40 and <40.
Results
A total of 238 patients underwent primary MAT during the study period, of which 212
patients (mean age, 28.5 ± 9.0 years; range, 15.01-53.67 years) met the inclusion
criteria with a mean follow-up of 5.1 ± 3.4 years (range 2.0-15.9 years). At final
follow-up, patients ≥40 and <40 years of age demonstrated statistically significant
improvements in nearly all PRO scores (P < .05 for both groups). There were no significant differences between either group
for achievement of minimal clinically important difference for International Knee
Documentation Committee (P = .48) or Knee Injury and Osteoarthritis Outcome Score symptoms (P = .76). Because of insufficient numbers, a statistically significant difference could
not be demonstrated in reoperation rate (≥40: 1.49 ± 1.77 years, <40: 1.87 ± 1.98
years, P = .591), failure rate (≥40: 7/32 [21.9%], <40: 19/180 [10.6%], P = .072), or complication rate (≥40: 2/32 [6.3%], <40: 12/180 [6.7%], P = .930) based on age. Both sexes showed a significant improvement in PROs, whereas
female patients were more likely to undergo revision surgery (P = .033), with no significant differences based on time to reoperation, failure, or
complication rates.
Conclusions
PROs similarly improved following MAT in both patients aged ≥40 and those <40 at final
follow-up with no significant differences in minimal clinically important difference
achievement rate, complication rate, reoperation rate, time to reoperation, or failure
rate between groups. Female patients may be more likely to undergo revision surgery
after MAT.
Level of Evidence
III; therapeutic retrospective comparison study.
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Article Info
Publication History
Published online: May 27, 2021
Accepted:
May 12,
2021
Received:
October 8,
2020
Footnotes
The authors report the following potential conflicts of interest or sources of funding: R.F. reports American Academy of Orthopaedic Surgeons , Board or committee member; AlloSource : paid presenter or speaker; American Orthopaedic Society for Sports Medicine : board or committee member; American Shoulder and Elbow Surgeons : board or committee member; Arthrex : paid presenter or speaker; research support; Arthroscopy Association of North America : board or committee member; Elsevier : publishing royalties, financial or material support; International Cartilage Restoration Society : board or committee member; International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine : board or; committee member; Journal of Shoulder and Elbow Surgery: Editorial or governing board; JRF : paid presenter or speaker; Orthopedics Today: editorial or governing board; Ossur : paid presenter or speaker; Smith & Nephew : research support. A.B.Y. reports grants from Arthrex ; other from JRF Ortho and Olympus ; grants from Organogenesis ; other from Patient IQ , Smith & Nephew , and Sparta Biomedical ; and grants from Vericel , outside the submitted work. Full ICMJE author disclosure forms are available for this article online, as supplementary material.
Identification
Copyright
© 2021 Published by Elsevier on behalf of the Arthroscopy Association of North America
