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Introducing the Orthoregeneration Network Foundation Review Articles: Guiding Tissue Regeneration and Biologic Therapies Into Practice

      Abstract

      In this issue of Arthroscopy, readers will find the first of what are designed to be a series of peer-reviewed Orthoregeneration Network (ON) Foundation review articles. The ON Foundation is an independent, nonprofit, international foundation dedicated to promoting research and education in the field of orthopaedic tissue regeneration. ON defines “Orthoregeneration … as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration” making use of treatments, including “drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electromagnetic stimuli.” The article is accessible and could be of interest to all readers, including clinicians, as well as basic scientists and researchers. It brings us great pleasure to collaborate with the ON Foundation and introduce the ON Foundation Reviews to the readers of Arthroscopy.
      In this issue of Arthroscopy, readers will find the first of what are designed to be a series of Orthoregeneration Network (ON) Foundation Review articles, “Nonoperative and Operative Soft-Tissue and Cartilage Regeneration and Orthopaedic Biologics of the Knee” by Knapik et al.
      • Knapik D.M.
      • Evuarherhe A.
      • Frank R.M.
      • Steinwachs M.
      • Rodeo S.
      • Mumme M.
      • Cole B.J.
      Nonoperative and operative soft-tissue and cartilage regeneration and orthopaedic biologics of the knee: An Orthoregeneration Network (ON) Foundation review.
      Future ON Foundation Reviews are expected and may focus on shoulder; elbow; wrist and hand; hip; foot and ankle; spine; and future prospects.
      The ON Foundation is an independent, nonprofit, international foundation dedicated to promoting research and education in the field of orthopaedic tissue regeneration. ON defines “Orthoregeneration … as a solution for orthopedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration” making use of treatments, including “drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electromagnetic stimuli.”
      Orthoregeneration Network Glossary.
      According to ON Executive Director, Dr. Kay Horsch, orthoregeneration is an “overarching concept that includes orthobiologics, but it is not limited to injectables. As an important part of our mission, we aim to provide guidance, education, and knowledge for surgeons to improve clinical practice within orthopaedic tissue regeneration and biologic therapies for the well-being of the patient. Sharing evidence in the form of peer-reviewed publications is an important activity within this mission.”
      As evidence of a shared commitment to this mission, Arthroscopy, Elsevier, and the ON Foundation have mutually invested to make these peer-reviewed, ON Foundation Reviews open access, meaning that the electronic version of these articles will be freely available to readers for unrestricted use without a subscription. In addition, as the field of orthoregeneration advances, we expect the ON Foundation to periodically publish updated reviews. We particularly acknowledge the efforts of Dr. Myron Spector, Honorary Member of the ON Foundation Board, and Dr. Brian Cole, in his role of Past-President of the ON Foundation Board and the AANA Board, for energizing this initiative from conception to fulfillment.
      The article by Knapik et al.
      • Knapik D.M.
      • Evuarherhe A.
      • Frank R.M.
      • Steinwachs M.
      • Rodeo S.
      • Mumme M.
      • Cole B.J.
      Nonoperative and operative soft-tissue and cartilage regeneration and orthopaedic biologics of the knee: An Orthoregeneration Network (ON) Foundation review.
      is detailed and delves into basic, as well as clinical science. Yet, the article should be accessible and of interest to all readers, including clinicians, as well as basic scientists and researchers, because the authors have organized their review by knee tissue type (articular cartilage, meniscus, tendon, and ligament) and by treatment option (hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrate, mesenchymal stromal cells, connective tissue progenitor cells, matrix-based cell therapy, vitamin D, and fibrin clot).
      If regeneration means growing new tissue to replace damaged or missing tissue, and if ON and ON Reviews comprehensively approach the upper and lower extremities and spine with an eye to the future, words that come to our minds include, “pioneering,” “ambitious,” or simply put, “Wow”! We’ll say it again, “Wow”! It brings us great pleasure to collaborate with the ON Foundation and introduce the ON Foundation Reviews to readers of Arthroscopy.

      References

        • Knapik D.M.
        • Evuarherhe A.
        • Frank R.M.
        • Steinwachs M.
        • Rodeo S.
        • Mumme M.
        • Cole B.J.
        Nonoperative and operative soft-tissue and cartilage regeneration and orthopaedic biologics of the knee: An Orthoregeneration Network (ON) Foundation review.
        Arthroscopy. 2021; 37: 2704-2721
      1. Orthoregeneration Network Glossary.
        (Available at)
        https://my.on-foundation.org/Glossary
        Date accessed: June 8, 2021