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Editorial Commentary| Volume 39, ISSUE 1, P88-90, January 2023

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Editorial Commentary: Autograft, Early Surgery, 2-Stage Surgery for 1 cm of Tunnel Widening or Greater, and Anterolateral Ligament Reconstruction or Lateral Extra-articular Tenodesis May Improve Outcomes of Anterior Cruciate Ligament Revision Surgery

      Abstract

      Revision anterior cruciate ligament reconstruction (ACLR) is a challenging procedure. Results are less satisfactory than those of primary ACLR owing to bone defects, altered anatomic landmarks, and concomitant injuries. Modifiable factors such as autograft, early surgery, 2-stage surgery for 1 cm of tunnel widening or greater, and anterolateral ligament reconstruction or lateral extra-articular tenodesis may improve outcomes of anterior cruciate ligament revision surgery. Finally, it is important to consider patients’ expectations after revision ACLR when counseling patients and making surgical decisions.
      Revision anterior cruciate ligament reconstruction (ACLR) is a challenging procedure. Its results are less satisfactory than those of primary ACLR owing to bone defects, altered anatomic landmarks, and severe concomitant injuries induced by additional injuries and prolonged instability.
      • Cristiani R.
      • Engström B.
      • Edman G.
      • Forssblad M.
      • Stålman A.
      Revision anterior cruciate ligament reconstruction restores knee laxity but shows inferior functional knee outcome compared with primary reconstruction.
      • Yoon K.H.
      • Kim J.H.
      • Kwon Y.B.
      • Kim E.J.
      • Kim S.-G.
      Re-revision anterior cruciate ligament reconstruction showed more laxity than revision anterior cruciate ligament reconstruction at a minimum 2-year follow-up.
      • Lefevre N.
      • Klouche S.
      • Mirouse G.
      • Herman S.
      • Gerometta A.
      • Bohu Y.
      Return to sport after primary and revision anterior cruciate ligament reconstruction: A prospective comparative study of 552 patients from the FAST Cohort.
      • Yoon K.H.
      • Kim J.S.
      • Park S.Y.
      • Park S.E.
      One-stage revision anterior cruciate ligament reconstruction: Results according to preoperative bone tunnel diameter: Five to fifteen-year follow-up.
      • Helito C.P.
      • Da Silva A.G.M.
      • Guimarães T.M.
      • Sobrado M.F.
      • Pécora J.R.
      • Camanho G.L.
      Functional results of multiple revision anterior cruciate ligament with anterolateral tibial tunnel associated with anterolateral ligament reconstruction.
      Sylvia, Toppo, Perrone, Miltenberg, Power, Richmond, and Salzler,
      • Sylvia S.M.
      • Toppo A.J.
      • Perrone G.S.
      • et al.
      Revision soft-tissue allograft anterior cruciate ligament reconstruction is associated with lower patient-reported outcomes compared with primary anterior cruciate ligament reconstruction in patients aged 40 and older.
      in their study “Revision Soft-Tissue Allograft Anterior Cruciate Ligament Reconstruction Is Associated With Lower Patient-Reported Outcomes Compared With Primary Anterior Cruciate Ligament Reconstruction in Patients Aged 40 and Older,” also highlight poor patient-reported outcomes (PROs) after revision ACLR in middle-aged patients. They found that revision allograft ACLRs in patients aged 40 years or older were associated with lower PROs compared with primary ACLRs. Patients who underwent revision ACLR failed to meet the patient acceptable symptom state (PASS) threshold for the International Knee Documentation Committee (IKDC) score more often and were dissatisfied with the results of the procedure more than twice as often as patients who underwent primary ACLR.
      The number of revision ACLRs has increased in recent years, with as many as 13,000 patients undergoing revision ACLR annually in the United States alone.
      • Leathers M.P.
      • Merz A.
      • Wong J.
      • Scott T.
      • Wang J.C.
      • Hame S.L.
      Trends and demographics in anterior cruciate ligament reconstruction in the United States.
      ,
      • Hettrich C.M.
      • Dunn W.R.
      • Reinke E.K.
      • Spindler K.P.
      MOON Group
      The rate of subsequent surgery and predictors after anterior cruciate ligament reconstruction: Two- and 6-year follow-up results from a multicenter cohort.
      Nevertheless, whether revision ACLR can achieve comparable clinical outcomes to those of primary ACLR remains an open question. However, this study may provide some clues to solving this problem.
      This study used soft-tissue allografts in both primary and revision ACLRs. A Multicenter Orthopaedic Outcomes Network (MOON) cohort study reported that the rate of graft rupture with allograft reconstruction is 4 times higher than that with autograft reconstruction.
      • Kaeding C.C.
      • Aros B.
      • Pedroza A.
      • et al.
      Allograft versus autograft anterior cruciate ligament reconstruction: Predictors of failure from a MOON prospective longitudinal cohort.
      It also showed that the difference in the risk of graft rerupture between autograft and allograft in young patients was greater than that in older patients. However, the results of this study do not imply that the use of allografts guarantees satisfactory outcomes in older patients. A Multicenter ACL Revision Study (MARS) cohort study evaluated the effect of graft choice on the outcomes of revision ACLR.
      MARS Group
      Effect of graft choice on the outcome of revision anterior cruciate ligament reconstruction in the Multicenter ACL Revision Study (MARS) cohort.
      It found that improved sports function, improved PROs, and a decreased risk of graft rerupture were obtained at 2 years’ follow-up when autograft was used. Moreover, Grossman
      • Grossman M.G.
      • ElAttrache N.S.
      • Shields C.L.
      • Glusman R.E.
      Revision anterior cruciate ligament reconstruction: three-to nine-year follow-up.
      et al. reported that allograft showed more laxity than autograft at 3 to 9 years’ follow-up after revision ACLR (3.21 mm vs 1.33 mm). The findings of these studies suggested that autograft should be used in primary or revision ACLR when possible to improve clinical outcomes and graft survivorship.
      Degenerative chondral and meniscal lesions are common in middle-aged patients during ACLR.
      • Brandsson S.
      • Kartus J.
      • Larsson J.
      • Eriksson B.I.
      • Karlsson J.
      A comparison of results in middle-aged and young patients after anterior cruciate ligament reconstruction.
      Moreover, a recent study reported that patients who underwent revision ACLR had more chondral lesions and higher-grade chondral lesions than those who underwent primary ACLR.
      • Mitchell J.J.
      • Cinque M.E.
      • Dornan G.J.
      • et al.
      Primary versus revision anterior cruciate ligament reconstruction: Patient demographics, radiographic findings, and associated lesions.
      In the current study by Sylvia et al.,
      • Sylvia S.M.
      • Toppo A.J.
      • Perrone G.S.
      • et al.
      Revision soft-tissue allograft anterior cruciate ligament reconstruction is associated with lower patient-reported outcomes compared with primary anterior cruciate ligament reconstruction in patients aged 40 and older.
      revision ACLR patients showed a longer duration between injury and surgery and the rate of concomitant meniscal repair was higher in the revision ACLR group (21.9% vs 6%, P = .007). Stone et al.
      • Stone J.A.
      • Perrone G.S.
      • Nezwek T.A.
      • et al.
      Delayed ACL reconstruction in patients ≥40 years of age is associated with increased risk of medial meniscal injury at 1 year.
      similarly reported that delayed ACLR in patients aged 40 years or older is associated with an increased risk of medial meniscal injury at 1 year. Therefore, immediate reconstruction for a failed ACLR may help decrease the possibility of arthritis developing as it has been associated with the duration between failure and revision ACLR.
      Published studies
      • Yoon K.H.
      • Kim J.S.
      • Park S.Y.
      • Park S.E.
      One-stage revision anterior cruciate ligament reconstruction: Results according to preoperative bone tunnel diameter: Five to fifteen-year follow-up.
      ,
      • Kim D.-H.
      • Bae K.-C.
      • Kim D.-W.
      • Choi B.-C.
      Two-stage revision anterior cruciate ligament reconstruction.
      have shown that proper management of tunnel widening is crucial for successful revision ACLR. Although there is still controversy about the amount of tunnel widening indicated for 2-stage revision ACLR, there seems to be a consensus that a large amount of tunnel widening can affect graft fixation and healing in revision ACLR. It has previously been reported in the literature that 2-stage surgery should be performed if the tunnel size exceeds 10 to 15 mm.
      • Yoon K.H.
      • Kim J.S.
      • Park S.Y.
      • Park S.E.
      One-stage revision anterior cruciate ligament reconstruction: Results according to preoperative bone tunnel diameter: Five to fifteen-year follow-up.
      ,
      • Kim D.-H.
      • Bae K.-C.
      • Kim D.-W.
      • Choi B.-C.
      Two-stage revision anterior cruciate ligament reconstruction.
      In addition, recent clinical studies have reported that anterolateral ligament reconstruction or lateral extra-articular tenodesis can improve the clinical outcomes and survivorship of revision ACLR.
      • Yoon K.H.
      • Hwang I.U.
      • Kim E.J.
      • Kwon Y.B.
      • Kim S.-G.
      Anterolateral ligament reconstruction improves anteroposterior stability as well as rotational stability in revision anterior cruciate ligament reconstruction with high-grade pivot shift.
      • Lee D.W.
      • Kim J.G.
      • Cho S.I.
      • Kim D.H.
      Clinical outcomes of isolated revision anterior cruciate ligament reconstruction or in combination with anatomic anterolateral ligament reconstruction.
      • Alm L.
      • Drenck T.C.
      • Frosch K.-H.
      • Akoto R.
      Lateral extra-articular tenodesis in patients with revision anterior cruciate ligament (ACL) reconstruction and high-grade anterior knee instability.
      The study by Sylvia et al.
      • Sylvia S.M.
      • Toppo A.J.
      • Perrone G.S.
      • et al.
      Revision soft-tissue allograft anterior cruciate ligament reconstruction is associated with lower patient-reported outcomes compared with primary anterior cruciate ligament reconstruction in patients aged 40 and older.
      has several limitations. Because this study was retrospective, recall bias could have influenced the results. The revision surgical procedures were performed by 4 different surgeons. In addition, the population, from a single center, may not be fully representative of all populations, and longer follow-up may better represent postoperative outcomes. The 2 groups in this study also differed regarding mean follow-up time and concomitant meniscal repair, which could influence the results. Finally, data from patients managed nonoperatively and preoperative PROs were unavailable for comparison between groups. However, these limitations do not outweigh the study’s benefit to the scientific literature. This study highlights poor PROs after revision ACLR in middle-aged patients, who have been shown to have lower expectations than younger patients.
      • Feucht M.J.
      • Cotic M.
      • Saier T.
      • et al.
      Patient expectations of primary and revision anterior cruciate ligament reconstruction.
      As Sylvia et al. mentioned in the “Discussion” section, patients’ expectations should be considered when counseling patients before revision ACLR. In addition, future research and efforts are needed to improve the clinical outcomes of revision ACLR.

      Supplementary Data

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