ABSTRACT
Purpose
This study aims to compare the efficacy of a single dose of Platelet-Rich Plasma (PRP)
with multiple doses of PRP therapy in the treatment of knee osteoarthritis (KOA).
Methods
PubMed, Embase, CINAHL, SCOPUS, Cochrane Library, grey literature and bibliographic
references were searched from inception to May 2022. Only randomized controlled trials
(RCTs) comparing the effect of single versus multiple doses of PRP for KOA were included.
Literature retrieval and data extraction were conducted by three independent reviewers.
Inclusion and exclusion criteria were based on type of study, research subjects, intervention,
outcome, language and availability of data. Pooled analysis of Visual Analogue Scale
(VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores and
adverse events were conducted.
Results
Seven studies (all RCTs) of high methodological quality involving 575 patients were
included. Age of patients included in this study ranged from 20 to 80, with a balanced
gender ratio. Single dose PRP therapy resulted in significantly better VAS scores
compared to triple dose PRP therapy at 12 months (P<0. 0001), with no significant
change in VAS scores between double and single dose PRP at 12 months. Regarding adverse
events, double dose (P=0.28) and triple dose (P=0.24) therapy had no significant differences
in safety from single dose therapy.
Conclusion
While there is a paucity of large high-quality Level I studies, current best evidence
suggests that two or three doses of PRP for KOA are as effective as one dose of PRP
at providing pain relief and improvement in function up to 1 year following administration.
Keywords
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Article info
Publication history
Accepted:
May 8,
2023
Received in revised form:
May 4,
2023
Received:
June 21,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Three doses of PRP therapy may be more effective than one dose of Platelet-Rich Plasma (PRP) in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis
Level of Evidence: II, systematic review of Level II studies
Identification
Copyright
© 2023 Published by Elsevier on behalf of the Arthroscopy Association of North America
