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- Clinical Musculoskeletal Biologics 2023 Special Issue
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- Cole, Brian J5
- Chahla, Jorge3
- Baldino, Joshua B2
- Gilat, Ron2
- Kia, Cameron2
- Mazzocca, Augustus D2
- McCarthy, Mary Beth2
- Muench, Lukas N2
- Afizah, Hassan1
- Anz, Adam W1
- Berthold, Daniel P1
- Bois, Aaron J1
- Bradley, James P1
- Brand, Jefferson C1
- Chen, Hong1
- Cinque, Mark E1
- Codina, David1
- Cote, Mark P1
- Coughlin, Ryan P1
- Davey, Martin S1
- Domb, Benjamin G1
- Dyrna, Felix1
- Farr, Jack1
- Flanigan, David C1
- Frazier, Landon1
Clinical Musculoskeletal Biologics 2023 Special Issue


In 2023, Brian Cole, MD, Guest Editor, and James Lubowitz, MD, Editor-in-Chief, selected these top, recent clinical musculoskeletal biologics articles published in Arthroscopy and Arthroscopy Techniques for inclusion in our first Biologics Special Issue.
In a Call For Papers, authors are encouraged to submit their orthobiologics research to our journals. Accepted articles may be awarded inclusion in future special issues.
20 Results
- Editorial
Orthopaedic Musculoskeletal Biologics Research Impacts Patient Care: The First Annual Arthroscopy Orthobiologics Virtual Special Issue
ArthroscopyVol. 39Issue 5p1117–1118Published in issue: May, 2023- Ryan Quigley
- Landon Frazier
- Brian J. Cole
Cited in Scopus: 0Orthobiologics can modify symptoms and improve healing in a variety of musculoskeletal conditions as a part of office-based care or as an adjunct to surgery. Orthobiologics harness the benefits of naturally derived blood components, autologous tissue, and growth factors to reduce inflammation and optimize the host-healing environment. The Arthroscopy family of journals seeks to positively influence evidence-based clinical decision-making by publishing peer-reviewed biologics research. This special issue contains recent influential articles strategically chosen to positively impact patient care. - Editorial
Arthroscopy and Musculoskeletal Biologics
ArthroscopyVol. 39Issue 5p1113–1116Published in issue: May, 2023- James H. Lubowitz
- Jefferson C. Brand
- Michael J. Rossi
Cited in Scopus: 0Orthopaedic biologics holds great promise. Absent peer-reviewed clinical musculoskeletal research, orthobiologics indications and treatment recommendations will remain opaque. In a Call for Papers, Arthroscopy; Arthroscopy Techniques; and Arthroscopy, Sports Medicine, and Rehabilitation editors invite authors to submit clinical musculoskeletal biologics original scientific research, and technical notes with video. Each year, the top articles will be awarded inclusion in an annual Biologics Special Issue. - Infographic
Platelet-Rich Plasma: Fundamentals and Clinical Applications
ArthroscopyVol. 37Issue 9p2732–2734Published in issue: September, 2021- Andrew J. Sheean
- Adam W. Anz
- James P. Bradley
Cited in Scopus: 12Platelet-rich plasma (PRP) is perhaps the most widely studied of the biologic therapies, with an ever-growing body of evidence supporting its safety and efficacy in decreasing inflammation and pain and promoting healing in the setting of both nonoperative and operative treatments. PRP is produced by the centrifugation of whole blood, isolating its constituent parts based on their unique densities. These density gradients can be selectively harvested so as to obtain different concentrations of various blood product components, such as platelets and leukocytes. - Original ArticleOpen Access
Safety and Efficacy of an Amniotic Suspension Allograft Injection Over 12 Months in a Single-Blinded, Randomized Controlled Trial for Symptomatic Osteoarthritis of the Knee
ArthroscopyVol. 37Issue 7p2246–2257Published online: March 11, 2021- Andreas H. Gomoll
- Jack Farr
- Brian J. Cole
- David C. Flanigan
- Christian Lattermann
- Bert R. Mandelbaum
- and others
Cited in Scopus: 20The purpose of this study is to determine the efficacy of amniotic suspension allograft (ASA) compared to hyaluronic acid (HA) and saline at up to 12 months of follow-up through the use of patient-reported outcomes, immunoglobulin levels, and anti-human leukocyte antigen (HLA) levels. - Meta-analysis
Platelet-Rich Plasma Combined With Hyaluronic Acid Improves Pain and Function Compared With Hyaluronic Acid Alone in Knee Osteoarthritis: A Systematic Review and Meta-analysis
ArthroscopyVol. 37Issue 4p1277–1287.e1Published online: December 2, 2020- Theofilos Karasavvidis
- Trifon Totlis
- Ron Gilat
- Brian J. Cole
Cited in Scopus: 21To evaluate the efficacy of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) injections versus HA injections alone for the management of knee osteoarthritis (OA). - Original Article
Platelet-Rich Plasma in Patients With Partial-Thickness Rotator Cuff Tears or Tendinopathy Leads to Significantly Improved Short-Term Pain Relief and Function Compared With Corticosteroid Injection: A Double-Blind Randomized Controlled Trial
ArthroscopyVol. 37Issue 2p510–517Published online: October 27, 2020- Cory A. Kwong
- Jarret M. Woodmass
- Eva M. Gusnowski
- Aaron J. Bois
- Justin Leblanc
- Kristie D. More
- and others
Cited in Scopus: 40To perform a randomized controlled trial comparing platelet-rich plasma (PRP) with standard corticosteroid (CS) injection in providing pain relief and improved function in patients with rotator cuff tendinopathy and partial-thickness rotator cuff tears (PTRCTs). - Original Article
Intra-Articular Platelet-Rich Plasma Combined With Hyaluronic Acid Injection for Knee Osteoarthritis Is Superior to Platelet-Rich Plasma or Hyaluronic Acid Alone in Inhibiting Inflammation and Improving Pain and Function
ArthroscopyVol. 37Issue 3p903–915Published online: October 19, 2020- Zhe Xu
- Zhixu He
- Liping Shu
- Xuanze Li
- Minxian Ma
- Chuan Ye
Cited in Scopus: 27To evaluate the effectiveness and explore the therapeutic mechanisms of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) as a treatment for knee osteoarthritis (KOA). - Meta-analysis
Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-analysis of 26 Randomized Controlled Trials
ArthroscopyVol. 37Issue 1p309–325Published online: July 14, 2020- Jixiang Tan
- Hong Chen
- Lin Zhao
- Wei Huang
Cited in Scopus: 31To compare the effectiveness and safety of platelet-rich plasma (PRP) and hyaluronic acid (HA) in patients with adult knee osteoarthritis (KOA) and to explore the most effective and safe protocol by using a meta-analysis method. - Research Article
Proximal Humerus and Ilium Are Reliable Sources of Bone Marrow Aspirates for Biologic Augmentation During Arthroscopic Surgery
ArthroscopyVol. 36Issue 9p2403–2411Published online: June 15, 2020- Alexander Otto
- Lukas N. Muench
- Cameron Kia
- Joshua B. Baldino
- Julian Mehl
- Felix Dyrna
- and others
Cited in Scopus: 17The purpose of this study was to evaluate the number of colony-forming units (CFUs) derived from concentrated bone marrow aspirates (BMAs) that were processed following arthroscopic harvest from either the proximal humerus or the body of the ilium during biologic augmentation of the rotator cuff and acetabular labral repairs. - Original Article
Subacromial Bursa–Derived Cells Demonstrate High Proliferation Potential Regardless of Patient Demographics and Rotator Cuff Tear Characteristics
ArthroscopyVol. 36Issue 11p2794–2802Published online: June 14, 2020- Lukas N. Muench
- Joshua B. Baldino
- Daniel P. Berthold
- Cameron Kia
- Amir Lebaschi
- Mark P. Cote
- and others
Cited in Scopus: 17To investigate the influence of patient demographics and rotator cuff tear characteristics on the cellular proliferation potential of subacromial bursa–derived cells (SBDCs). - Systematic Review
Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects: A Systematic Review and Meta-analysis
ArthroscopyVol. 37Issue 1p362–378Published online: June 1, 2020- Bhargavi Maheshwer
- Evan M. Polce
- Katlynn Paul
- Brady T. Williams
- Theodore S. Wolfson
- Adam Yanke
- and others
Cited in Scopus: 39To perform a systematic review and meta-analysis evaluating the effects of mesenchymal stem cells (MSCs) on cartilage regeneration and patient-reported pain and function. - Meta-analysis
Intra-Articular Injections of Hyaluronic Acid or Steroids Associated With Better Outcomes Than Platelet-Rich Plasma, Adipose Mesenchymal Stromal Cells, or Placebo in Knee Osteoarthritis: A Network Meta-analysis
ArthroscopyVol. 37Issue 1p292–306Published online: April 16, 2020- Seung-Beom Han
- In-Wook Seo
- Young-Soo Shin
Cited in Scopus: 33To evaluate the clinical effects of hyaluronic acid (HA), steroids, platelet-rich plasma (PRP), or adipose mesenchymal stromal cell (MSC) injections in the treatment of knee osteoarthritis (OA). - Original Article
Intra-Articular Injections of Mesenchymal Stem Cell Exosomes and Hyaluronic Acid Improve Structural and Mechanical Properties of Repaired Cartilage in a Rabbit Model
ArthroscopyVol. 36Issue 8p2215–2228.e2Published online: April 14, 2020- Keng Lin Wong
- Shipin Zhang
- Ming Wang
- Xiafei Ren
- Hassan Afizah
- Ruenn Chai Lai
- and others
Cited in Scopus: 50To compare the efficacy of mesenchymal stem cell (MSC) exosomes with hyaluronic acid (HA) against HA alone for functional cartilage regeneration in a rabbit osteochondral defect model. - Systematic Review
Platelet-Rich Plasma Augmentation in Meniscal Repair Surgery: A Systematic Review of Comparative Studies
ArthroscopyVol. 36Issue 6p1765–1774Published online: February 10, 2020- Eric D. Haunschild
- Hailey P. Huddleston
- Jorge Chahla
- Ron Gilat
- Brian J. Cole
- Adam B. Yanke
Cited in Scopus: 24To systematically review the literature on meniscal repair surgery and assess functional and radiographic outcomes of platelet-rich plasma (PRP)–augmented repair compared with standard repair techniques. - Systematic Review
Anterior Cruciate Ligament Reconstruction with Platelet-Rich Plasma: A Systematic Review of Randomized Control Trials
ArthroscopyVol. 36Issue 4p1204–1210Published online: January 24, 2020- Martin S. Davey
- Eoghan T. Hurley
- Dan Withers
- Ray Moran
- Cathal J. Moran
Cited in Scopus: 24To perform a systematic review of the randomized controlled trials (RCTs) evaluating the efficacy of platelet-rich plasma (PRP) to augment anterior cruciate ligament (ACL) reconstruction. - Meta-analysis
Different Intra-articular Injections as Therapy for Hip Osteoarthritis: A Systematic Review and Network Meta-analysis
ArthroscopyVol. 36Issue 5p1452–1464.e2Published online: January 13, 2020- Zhihu Zhao
- Jian-xiong Ma
- Xin-long Ma
Cited in Scopus: 34This systematic review and network meta-analysis aimed to compare the clinical outcomes between 4 intra-articular injections (platelet-rich plasma [PRP], hyaluronic acid [HA], corticosteroid [CS], and HA plus PRP) for hip osteoarthritis (OA). - Systematic Review
Platelet-Rich Plasma Versus Surgery for the Management of Recalcitrant Greater Trochanteric Pain Syndrome: A Systematic Review
ArthroscopyVol. 36Issue 3p875–888Published online: December 24, 2019- Rafael Walker-Santiago
- Natalia M. Wojnowski
- Ajay C. Lall
- David R. Maldonado
- Stephanie M. Rabe
- Benjamin G. Domb
Cited in Scopus: 17To perform a systematic review of the outcomes of platelet-rich plasma (PRP) injections as an in-office procedure versus surgical treatment for recalcitrant greater trochanteric pain syndrome (GTPS). - Original Article
The Effect of Delayed Injection of Leukocyte-Rich Platelet-Rich Plasma Following Rotator Cuff Repair on Patient Function: A Randomized Double-Blind Controlled Trial
ArthroscopyVol. 36Issue 3p648–657Published online: November 27, 2019- Martyn Snow
- Faisal Hussain
- Joseph Pagkalos
- Tomasz Kowalski
- Marcus Green
- Samir Massoud
- and others
Cited in Scopus: 25To investigate the effect of delayed application of leukocyte-rich platelet-rich plasma (PRP) on rotator cuff repair results as assessed by outcome scores and imaging at one year. - Technical NoteOpen Access
Adipose-Derived Stem Cell Transplant Technique for Degenerative Joint Disease
Arthroscopy TechniquesVol. 6Issue 5e1761–e1766Published online: October 2, 2017- Ryan P. Coughlin
- Alexander Oldweiler
- Dayne T. Mickelson
- Claude T. Moorman III
Cited in Scopus: 18The treatment of mild to moderate osteoarthritis can be a challenging problem for orthopaedic surgeons. As new research and treatment strategies have emerged, stem cell therapy has risen in popularity for the management of degenerative joint conditions. In this article, we describe a stepwise technical approach with tips and pearls to performing adipose-derived stem cell transplantation for degenerative joint disease of the knee. - Technical NoteOpen Access
Bone Marrow Aspirate Concentrate Harvesting and Processing Technique
Arthroscopy TechniquesVol. 6Issue 2e441–e445Published online: April 10, 2017- Jorge Chahla
- Sandeep Mannava
- Mark E. Cinque
- Andrew G. Geeslin
- David Codina
- Robert F. LaPrade
Cited in Scopus: 73Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors. Recent studies have reported good to excellent outcomes with the use of bone marrow aspirate concentrate (BMAC) for pain relief in the treatment of focal chondral lesions and osteoarthritis of the knee. However, the harvesting and processing technique are crucial to achieve satisfactory results. Several studies have examined outcomes after BMAC injection, with encouraging results, but there is a lack of consensus in terms of the frequency of injection, the amount of BMAC that is injected, and the timing of BMAC injections.